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AB272341

APC Anti-Sialoadhesin/CD169 antibody [7-239]

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Mouse Monoclonal Sialoadhesin/CD169 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing SIGLEC1 protein.

View Alternative Names

CD169, SN, SIGLEC1, Sialoadhesin, Sialic acid-binding Ig-like lectin 1, Siglec-1

3 Images
Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [7-239] (AB272341)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [7-239] (AB272341)

Flow cytometry multicolor surface staining of human TNF-α and INF-γ stimulated peripheral blood mononuclear cells stained using ab272341 at 10 μl reagent per milion cells in 100 μl of cell suspension and anti-human CD11c (BU15) FITC antibody (20 μl reagent / 100 μl of peripheral whole blood).

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [7-239] (AB272341)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [7-239] (AB272341)

Separation of human CD169 positive CD11c positive cells (red-filled) from CD169 negative CD11c negative cells (black-dashed) in flow cytometry analysis (surface staining) of human TNF-α and INF-γ stimulated peripheral blood mononuclear cells stained using ab272341 at 10 μl reagent per milion cells in 100 μl of cell suspension.

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [7-239] (AB272341)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [7-239] (AB272341)

Flow cytometry surface staining pattern of human TNF-α and INF-γ stimulated peripheral blood mononuclear cells stained using ab272341 at 10 μl reagent per milion cells in 100 μl of cell suspension.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

7-239

Isotype

IgG1

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing SIGLEC1 protein. The exact immunogen used to generate this antibody is proprietary information.

Q9BZZ2

Epitope

Extracellular

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10<sup>6</sup> cells in a suspension.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed : 12940982, PubMed : 33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed : 28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed : 28129379, PubMed : 34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed : 12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed : 26358190).. (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane.
See full target information SIGLEC1
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Product promise

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