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AB317480

APC Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

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Rabbit Recombinant Monoclonal Sialoadhesin/CD169 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Mouse samples.

View Alternative Names

CD169, Sa, Sn, Siglec1, Sialoadhesin, Sheep erythrocyte receptor, Sialic acid-binding Ig-like lectin 1, SER, Siglec-1

2 Images
Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB317480)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB317480)

Flow cytometric analysis of Mouse bone marrow cells cells labelling Sialoadhesin/CD169 with ab317480 at 1/5000 dilution (0.01ug) / Right compared with a Rabbit IgG monoclonal [EPR25A] - Isotype Control (Allophycocyanin) (ab232814) / Left isotype control.

Gated on viable cell. Mouse bone marrow cells are co-stained with F4/80 conjugated PE.

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB317480)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-Sialoadhesin/CD169 antibody [EPR27102-11] (AB317480)

Flow cytometric analysis of Mouse bone marrow cells cells labelling Sialoadhesin/CD169 with ab317480 at 1/5000 dilution (0.01ug) / Right compared with a Rabbit IgG monoclonal [EPR25A] - Isotype Control (Allophycocyanin) (ab232814) / Left isotype control.

Gated on viable cell. Mouse bone marrow cells are co-stained with CD3 conjugated Alexa Fluor®488.

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

  • 578 PE

    PE Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

  • Unconjugated

    Anti-Sialoadhesin/CD169 antibody [EPR27102-11]

  • Carrier free

    Anti-Sialoadhesin/CD169 antibody [EPR27102-11] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR27102-11

Isotype

IgG

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/5000", "FlowCyt-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed : 24788876). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed : 26370074). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus (PubMed : 26370074). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (By similarity).
See full target information Siglec1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com