JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB270636

APC Anti-TACI antibody [1A1]

Be the first to review this product! Submit a review

|

(0 Publication)

Rat Monoclonal TACI antibody - conjugated to APC. Carrier free. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing TNFRSF13B protein.

View Alternative Names

CD267, TACI, TNFRSF13B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor

3 Images
Flow Cytometry - APC Anti-TACI antibody [1A1] (AB270636)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-TACI antibody [1A1] (AB270636)

Flow cytometry analysis of human peripheral whole blood cells labeling TACI (CD267) using ab270636. The concentration was 10 μl reagent / 100μl of peripheral whole blood.

Flow Cytometry - APC Anti-TACI antibody [1A1] (AB270636)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-TACI antibody [1A1] (AB270636)

Flow cytometry analysis of human TACI (CD267) positive lymphocytes (red) and human TACI negative lymphocytes (black) cells labeling TACI using ab270636. Concentration of 10 μl reagent / 100μl peripheral whole blood.

Flow Cytometry - APC Anti-TACI antibody [1A1] (AB270636)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-TACI antibody [1A1] (AB270636)

Flow cytometric analysis of human lymphocytes labeling TACI (CD267) using ab270636. The concentration of 10 μl reagent/ 100μl of peripheral whole blood. Negative control is anti-human CD19 PE antibody.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

1A1

Isotype

IgG2a

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

Yes

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing TNFRSF13B protein. The exact immunogen used to generate this antibody is proprietary information.

O14836

style
left-column

Complementary Products

Assay Kits

AB288592

Human TACI ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human TACI ELISA Kit (AB288592)

  • 0
  • 0
Primary Antibodies

AB178872

Anti-IKK gamma/NEMO antibody [EPR16629]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IKK gamma/NEMO antibody [EPR16629] (AB178872)

  • 5
  • 1
Primary Antibodies

AB253242

Anti-BCMA antibody [EPR22457-260]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-BCMA antibody [EPR22457-260] (AB253242)

  • 0
  • 0
Primary Antibodies

AB155288

Anti-VEGFD antibody [EPR8457]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFD antibody [EPR8457] (AB155288)

  • 0
  • 0
Primary Antibodies

AB221154

Anti-TIE2 antibody [EPR21915]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-TIE2 antibody [EPR21915] (AB221154)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Transmembrane Activator and CAML Interactor known as TACI also goes by the names TNFRSF13B and CD267. TACI is a receptor with a molecular weight of approximately 33 kDa. It is expressed on B cells a type of lymphocyte and to some extent on activated T cells. This receptor plays a part in the immune system helping manage the production and function of certain antibodies.
Biological function summary

TACI involves the regulation of B cell function and survival. It binds to two ligands APRIL and BAFF and TACI is not part of any larger complex. Upon ligand binding TACI can promote antibody class-switching which adjusts the type of antibody that B cells produce. This action supports the immune response by allowing the body to adapt to different pathogens effectively.

Pathways

Immune responses involve TACI in the BAFF-APRIL signaling pathway. The interplay between TACI and its ligands influences the NF-kB signaling cascade leading to B cell proliferation and survival. TACI interacts with other proteins such as BCMA and BAFF-R which are important in regulating B cell homeostasis and function ensuring balanced and effective immune responses.

Aberrant TACI function contributes to conditions like Common Variable Immunodeficiency (CVID) and Systemic Lupus Erythematosus (SLE). In CVID mutations in the TACI gene may lead to impaired antibody production resulting in frequent infections. In the context of SLE TACI's interactions with BAFF and APRIL can contribute to the overactivation of B cells causing autoimmune characteristics of the disease. TACI's role in these conditions makes it a focus for studying therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
See full target information TNFRSF13B
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com