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AB319279

APC Anti-V2R antibody [EPR24555-59]

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Rabbit Recombinant Monoclonal V2R antibody - conjugated to APC.

View Alternative Names

ADHR, DIR, DIR3, V2R, AVPR2, Vasopressin V2 receptor, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR24555-59

Isotype

IgG

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The V2R or vasopressin receptor 2 is a G protein-coupled receptor with a mass of approximately 40 kDa. It is also known as the antidiuretic hormone receptor. Most expression of V2R occurs in the renal collecting ducts specifically on the basolateral surface of cells. This receptor mainly binds to arginine vasopressin an antidiuretic hormone facilitating the reabsorption of water in the kidneys.
Biological function summary

V2R plays an important role in maintaining water balance and homeostasis within the body. It is not a part of a larger complex but interacts with adenylate cyclase through the Gs protein pathway promoting cAMP generation. This increase in cAMP levels leads to the insertion of aquaporin-2 channels into the apical membrane enhancing water permeability and therefore water reabsorption in the kidney.

Pathways

The activity of V2R closely links to water regulation and osmoregulation pathways. It interacts with proteins such as aquaporin-2 as mentioned which are key in the transport of water. V2R's function connects to other signaling pathways including those involving other G protein-coupled receptors which mediate different physiological responses.

V2R dysfunction is associated with conditions such as nephrogenic diabetes insipidus and the syndrome of inappropriate antidiuretic hormone secretion (SIADH). In nephrogenic diabetes insipidus mutations in the receptor prevent normal function leading to excessive urination. This condition often involves aquaporin-2 due to its role in the same pathway. In SIADH hyperactive V2R elicits excessive water reabsorption which can result in water retention and hyponatremia.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
See full target information AVPR2
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Product promise

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For full details, please see our Terms & Conditions

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