Anti-APC2 antibody [3A2G2]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

APC2 also known as Adenomatous Polyposis Coli 2 is a critical regulator of cell function primarily involved in the cell cycle and stability of beta-catenin. This protein has a molecular mass of approximately 260 kDa and is mainly expressed in neural tissue and embryonic development stages. APC2 shares structural similarities with APC1 including the presence of armadillo repeats which facilitate protein-protein interactions necessary for its function.

Biological function summary

APC2 interacts with cytoskeletal networks and contributes to cellular architecture and mobility. It is a component of the WNT signaling cascade mainly directing the degradation of beta-catenin which prevents irregular cell proliferation. APC2 forms part of the destruction complex working alongside proteins like Axin and GSK3β to regulate beta-catenin levels within cells.

Pathways

APC2 plays a significant role in the WNT signaling pathway important for cellular growth and communication. Through this pathway APC2 interacts with various proteins such as beta-catenin and GSK3β controlling their activity and stability. Its function in this pathway impacts gene expression which is critical for processes like embryonic development and adult tissue homeostasis.

Associated diseases and disorders

Mutations or dysregulation of APC2 have been associated with colorectal cancer and neural developmental anomalies. These conditions often involve aberrations in the WNT signaling pathway where APC2 fails to regulate beta-catenin adequately. Research has linked APC2 with APC1 where both proteins contribute to oncogenic processes when their regulatory roles in beta-catenin degradation are compromised.