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AB73063

Anti-APCDD1 antibody

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(1 Publication)

Mouse Polyclonal APCDD1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human APCDD1.

View Alternative Names

DRAPC1, FP7019, APCDD1, Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein

1 Images
Western blot - Anti-APCDD1 antibody (AB73063)
  • WB

Unknown

Western blot - Anti-APCDD1 antibody (AB73063)

All lanes:

Western blot - Anti-APCDD1 antibody (ab73063) at 1 µg/mL

Lane 1:

APCDD1 transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 59 kDa

Observed band size: 70 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human APCDD1.

Q8J025

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Primary Antibodies

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RabMAb|Recombinant

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB70213

Anti-CDK5RAP2 antibody

Immunoprecipitation - Anti-CDK5RAP2 antibody (AB70213)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APCDD1 also known as Adenomatosis Polyposis Coli Down-Regulated 1 is a membrane-bound protein involved in the regulation of cell proliferation and differentiation. APCDD1 has a molecular weight of approximately 42 kDa and is predominantly expressed in hair follicles but also found in other tissues such as skin and brain. Its expression often correlates with developmental stages indicating its role in cell growth processes.
Biological function summary

APCDD1 regulates cellular signaling by inhibiting Wnt/β-catenin signaling pathway an important pathway involved in cell fate determination and proliferation. APCDD1 does not function as a classic receptor or kinase but it modulates activity by interacting with other components of this pathway. It is often implicated in controlling the balance between cell proliferation and differentiation particularly in skin tissue.

Pathways

The Wnt/β-catenin signaling pathway features importantly in APCDD1's activities. This pathway critical for regulating embryonic development and adult tissue homeostasis involves interaction with proteins such as β-catenin and LRP5/6 receptors. APCDD1's inhibitory effects contribute to the modulation of these downstream signaling events linking it closely with the regulation of cellular growth and preventing excessive proliferation.

Hair loss conditions such as hereditary hypotrichosis simplex relate to APCDD1 due to its role in follicle development. Mutations or dysregulation of APCDD1 interrupt normal Wnt pathway inhibition leading to altered hair growth cycles. Additionally colorectal cancer is associated with changes in APCDD1 activity where aberrant Wnt signaling plays a role in tumorigenesis. In these diseases proteins like APC and β-catenin become central to the pathological processes influenced by APCDD1 activity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
See full target information APCDD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 14:4845-4852 PubMed29085490

2017

APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sung-Gook Cho
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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