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AB192481

Anti-APLP1 antibody

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(3 Publications)

Rabbit Polyclonal APLP1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human APLP1.

View Alternative Names

Amyloid beta precursor like protein 1, Amyloid beta (A4) precursor-like protein 1, Amyloid-like protein 1, APLP, APLP-1, APLP1

1 Images
Western blot - Anti-APLP1 antibody (AB192481)
  • WB

Supplier Data

Western blot - Anti-APLP1 antibody (AB192481)

All lanes:

Western blot - Anti-APLP1 antibody (ab192481) at 1/500 dilution

All lanes:

Mouse Brain lysate

Predicted band size: 72 kDa

Observed band size: 97 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human APLP1.

P51693

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Complementary Products

Assay Kits

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Proteins & Peptides

AB276580

Recombinant Human APLP1 protein (His tag)

SDS-PAGE - Recombinant Human APLP1 protein (His tag) (AB276580)

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Primary Antibodies

AB32136

Anti-Amyloid Precursor Protein antibody [Y188]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amyloid Precursor Protein antibody [Y188] (AB32136)

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Sample Prep & Detection Kits

AB201795

Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link®

ELISA - Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link® (AB201795)

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Primary Antibodies

AB32942

Anti-SV2A antibody

Western blot - Anti-SV2A antibody (AB32942)

  • 4
  • 8
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APLP1 also known as amyloid precursor-like protein 1 is a protein with a molecular mass of approximately 91 kDa. Researchers have observed its expression in the brain particularly in regions like the cortex and hippocampus. This protein shares structural similarities with the Amyloid Precursor Protein (APP) family and plays important roles in cellular functions through its protein domains and motifs.
Biological function summary

APLP1 functions by contributing to cell-cell adhesion and synaptic formation impacting neuronal development. It forms part of a larger protein complex that modulates these processes interacting with other proteins to maintain cellular communication. This protein's activity supports the stability and plasticity of synapses which is essential for proper neural network function.

Pathways

Proteins related to APLP1 participate notably in the Notch signaling and MAPK pathways. These pathways influence cell fate decisions growth and survival. APLP1 interacts with proteins such as APP and APLP2 both of which also engage in similar signaling pathways. This interconnectedness highlights APLP1's role in neurobiological processes essential for normal brain operation.

Researchers link APLP1 to neurodegenerative disorders like Alzheimer's disease and autism spectrum disorders. Changes in APLP1 expression or function can affect amyloidogenic processing connecting it to APP and potentially leading to plaque formation a hallmark of Alzheimer's disease. Additionally this protein's relationship with synaptic function may contribute to the pathophysiology observed in autism spectrum disorders where alterations in synaptic communication are common.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
See full target information APLP1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eado6894 PubMed39742488

2025

Blood-derived APLP1 extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Yuri Choi,Jae Hyun Park,Ala Jo,Chul-Woo Lim,Ji-Min Park,Jin Woo Hwang,Kang Soo Lee,Young-Sang Kim,Hakho Lee,Jisook Moon

Science translational medicine 12: PubMed33239387

2020

Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.

Applications

Unspecified application

Species

Unspecified reactive species

Sabrina Simoes,Jessica L Neufeld,Gallen Triana-Baltzer,Setareh Moughadam,Emily I Chen,Milankumar Kothiya,Yasir H Qureshi,Vivek Patel,Lawrence S Honig,Hartmuth Kolb,Scott A Small

The Journal of biological chemistry 291:21903-21912 PubMed27563067

2016

Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Paschkowsky,Mehdi Hamzé,Felix Oestereich,Lisa Marie Munter
View all publications
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Product promise

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