AB137597

Anti-APLP2 antibody

Name: Anti-APLP2 antibody (ab137597) | Abcam
Brand: Abcam Limited
SKU: AB137597
Price: 520 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal APLP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human APLP2 aa 1-250.

View Alternative Names

APPL2, APLP2, Amyloid beta precursor like protein 2, APPH, Amyloid beta (A4) precursor-like protein 2, Amyloid protein homolog, Amyloid-like protein 2, CDEI box-binding protein, Sperm membrane protein YWK-II, APLP-2, CDEBP

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APLP2 antibody (AB137597)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APLP2 antibody (AB137597)

Paraffin-embedded mouse fore brain tissue stained for APLP2 using ab137597 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APLP2 antibody (AB137597)

Paraffin-embedded mouse liver tissue stained for APLP2 using ab137597 at 1/500 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-APLP2 antibody (AB137597)

All lanes:

Western blot - Anti-APLP2 antibody (ab137597) at 1/1000 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 30 µg

Lane 2:

A431 (human epidermoid carcinoma cell line) whole cell lysate at 30 µg

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 30 µg

Lane 4:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 30 µg

Lane 5:

A-375 (human malignant melanoma cell line) whole cell lysate at 30 µg

Predicted band size: 87 kDa

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Supplier Data

Western blot - Anti-APLP2 antibody (AB137597)

All lanes:

Western blot - Anti-APLP2 antibody (ab137597) at 1/1000 dilution

All lanes:

Mouse brain lysate at 50 µg

Predicted band size: 87 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human APLP2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q06481

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APLP2 also known as Amyloid Precursor-Like Protein 2 is a cell surface protein with a mass of about 92 kDa. This protein belongs to the same family as Amyloid Precursor Protein (APP). APLP2 is notably expressed in many tissues including the brain where its expression is significant. It participates in a variety of cellular functions due to its structural and functional properties similar to that of other amyloid precursor proteins.

Biological function summary

APLP2 participates in the regulation of neuronal growth and synaptic stability. It functions as a part of a larger protein complex and shares structural similarities with other members of its family which suggests overlapping functions. APLP2 interacts with extracellular matrix proteins and may help with cell adhesion processes which are important for maintaining tissue structure and function.

Pathways

The APLP2 protein interacts within signaling pathways that regulate neural development and cell viability. It plays a role in the Notch signaling pathway which is important for cell differentiation processes. Other related proteins such as APP and APLP1 demonstrate similar roles within these pathways indicating a potential coordination among these family members to achieve functional outcomes in tissue development and homeostasis.

APLP2 has been implicated in neurodegenerative diseases such as Alzheimer's disease through its relation to APP. Elevated or misregulated levels of APLP2 have shown connections to increased amyloid-beta production which is a hallmark of Alzheimer's pathology. Furthermore APLP2's involvement in tumorigenesis links it to gliomas with its interaction with proteins like EGFR hinting at its role in cancer-related cellular signaling.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

See full target information APLP2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37240030

2023

Low Magnesium Concentration Enforces Bone Calcium Deposition Irrespective of 1,25-Dihydroxyvitamin D Concentration.

Applications

Unspecified application

Species

Unspecified reactive species

Usman Rashid,Sandra K Becker,Gerhard Sponder,Susanne Trappe,Mansur A Sandhu,Jörg R Aschenbach

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-APLP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APLP2 antibody (AB137597)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APLP2 antibody (AB137597)

Western blot - Anti-APLP2 antibody (AB137597)

Western blot - Anti-APLP2 antibody (AB137597)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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