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AB221453

Anti-APMAP antibody

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(1 Publication)

Rabbit Polyclonal APMAP antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human APMAP aa 150 to C-terminus.

View Alternative Names

C20orf3, UNQ1869/PRO4305, APMAP, Adipocyte plasma membrane-associated protein, Protein BSCv

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-APMAP antibody (AB221453)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-APMAP antibody (AB221453)

Immunofluorescent analysis of paraformaldehyde-fixed, Triton X-100 permeabilized U-2 OS cells labeling APMAP with ab221453 at 4 μg/mL dilution (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human APMAP aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9HDC9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APMAP also known as adipocyte plasma membrane-associated protein is an integral membrane protein that weighs approximately 45 kDa. APMAP localizes primarily in adipose tissues and hepatocytes. This protein resides within both the plasma membrane and intracellular compartments. APMAP participates in lipid metabolism through its interactions with various protein complexes. Its expression levels vary across different tissues reflecting a specialized role in certain physiological functions.
Biological function summary

APMAP functions within the modulation of lipid homeostasis especially in adipocytes. It shows involvement in triglyceride metabolism by regulating enzyme activity responsible for lipid turnover. APMAP acts as a part of a protein complex that includes enzymes affecting lipid storage and release. Through such interactions APMAP influences key biological processes that maintain lipid balance supporting energy homeostasis in mammals.

Pathways

APMAP integrates into the lipid metabolic pathway particularly those impacting triglyceride storage and hydrolysis. APMAP associates with proteins like perilipin which also participate in lipid droplet formation and breakdown. Additionally APMAP's involvement with AMP-activated protein kinase (AMPK) signaling influences cellular energy status linking it to pathways controlling metabolism and energy sensing.

APMAP shows association with metabolic syndrome and type 2 diabetes. Its role in lipid metabolism connects APMAP to insulin signaling pathways where altered expression or function may contribute to these metabolic disorders. APMAP's relationship with adiponectin a protein with anti-diabetic properties indicates its potential impact on glucose metabolism dysregulation. Understanding APMAP's function helps unravel molecular underpinnings of metabolic diseases offering insights for targeted therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.
See full target information APMAP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 12: PubMed37882444

2023

Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lars N Royall,Diana Machado,Sebastian Jessberger,Annina Denoth-Lippuner
View all publications
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Product promise

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