Anti-APOA1 antibody [EPR25446-9]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

APOA1 also known as Apolipoprotein A-I plays an important role in lipid metabolism. Mechanically APOA1 acts as the major protein component of high-density lipoprotein (HDL) in plasma. It facilitates cholesterol efflux from tissues to the liver for excretion. With a molecular weight of approximately 28 kDa APOA1 is expressed mainly in the liver and small intestine. This protein is also involved in lecithin-cholesterol acyltransferase (LCAT) activation which is important for the maturation of HDL particles.

Biological function summary

APOA1 is instrumental in reverse cholesterol transport a process that removes excess cholesterol from cells and prevents lipid accumulation. APOA1 is part of the HDL complex and it directly interacts with various lipid molecules. It contributes to lipid homeostasis and has antioxidant properties reducing oxidative stress. APOA1 also has anti-inflammatory effects which play a role in maintaining cardiovascular health.

Pathways

The reverse cholesterol transport pathway is highly reliant on APOA1 functionality supporting cholesterol movement out of cells. In this pathway APOA1 interacts with ATP-binding cassette transporters like ABCA1 and ABCG1 which aid in transferring cholesterol to HDL particles. Additionally APOA1 is associated with the HDL metabolism pathway where it collaborates with other proteins such as Apolipoprotein A-II (APOA2) and Lecithin-Cholesterol Acyltransferase (LCAT) facilitating the conversion of nascent HDL into mature HDL.

Associated diseases and disorders

APOA1 has significant implications in cardiovascular diseases and dyslipidemia. Deficiency or dysfunction of APOA1 can lead to lowered HDL levels which correlates with an increased risk of atherosclerosis and coronary artery disease. Furthermore research shows a connection between APOA1 and amyloid-related diseases; abnormal processing or accumulation of apolipoprotein A-I can contribute to amyloidosis. The interactions with proteins like Apolipoprotein E (APOE) are noted as APOE plays a role in lipid metabolism and is implicated in neurodegenerative disorders such as Alzheimer's disease.