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AB75114

Anti-APOA1BP antibody

5

(1 Review)

|

(2 Publications)

Rabbit Polyclonal APOA1BP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.

View Alternative Names

AIBP, APOA1BP, YJEFN1, NAXE, NAD(P)H-hydrate epimerase, Apolipoprotein A-I-binding protein, NAD(P)HX epimerase, YjeF N-terminal domain-containing protein 1, AI-BP, YjeF_N1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-APOA1BP antibody (AB75114)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-APOA1BP antibody (AB75114)

Immunofluorescence analysis of APOA1BP in A549 cells, using ab75114, at 1/500 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

Western blot - Anti-APOA1BP antibody (AB75114)
  • WB

Unknown

Western blot - Anti-APOA1BP antibody (AB75114)

All lanes:

Western blot - Anti-APOA1BP antibody (ab75114) at 1/500 dilution

Lane 1:

Extracts from HeLa cells at 20 µg

Lane 2:

Extracts from HeLa cells at 20 µg with immunizing peptide

Predicted band size: 32 kDa

Observed band size: 29 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APOA1BP also known as apolipoprotein A1 binding protein plays important roles in cellular lipid homeostasis and metabolism. This protein weighs approximately 28 kDa. APOA1BP is present in various tissues prominently in the mitochondria within liver and kidney cells. It displays binding affinity with apolipoprotein A1 which is an essential component of high-density lipoprotein (HDL).
Biological function summary

APOA1BP aids in stabilizing cellular processes that regulate lipid transport and cholesterol efflux. It works in close association with apolipoprotein A1 forming a functional complex that helps maintain lipid balance within cells. This interaction supports numerous cellular functions that are significant for normal metabolic activity.

Pathways

APOA1BP integrates into the reverse cholesterol transport pathway which is vital for recycling cholesterol from peripheral tissues back to the liver for excretion. It influences interactions with significant proteins such as HDL and other apolipoproteins contributing to cholesterol metabolism. Another related pathway involves lipid absorption where APOA1BP functions to facilitate efficient lipid distribution.

APOA1BP connects to cardiovascular disease due to its role in cholesterol metabolism and lipid transport. Disorders like atherosclerosis can occur when this protein's function in cholesterol efflux is impaired. Additionally APOA1BP links to inherited lipid disorders where its connection with apolipoprotein A1 and HDL becomes important in managing cholesterol levels and preventing disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed : 27616477). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed : 23719382).
See full target information NAXE
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 20:60 PubMed35525979

2022

Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Duan,Hainan Chen,Linjie Yin,Xiao Zhu,Petr Novák,Yuncheng Lv,Guojun Zhao,Kai Yin

JCI insight 3: PubMed30135304

2018

AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Soo-Ho Choi,Aaron M Wallace,Dina A Schneider,Elianne Burg,Jungsu Kim,Elena Alekseeva,Niki Dj Ubags,Carlyne D Cool,Longhou Fang,Benjamin T Suratt,Yury I Miller
View all publications
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