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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Recombinant Monoclonal ApoER2 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.
IgG
Rabbit
Constituents: 100% PBS
Liquid
Monoclonal
sELISA | |
---|---|
Human | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).
Low-density lipoprotein receptor-related protein 8, LRP-8, Apolipoprotein E receptor 2, LRP8, APOER2
Rabbit Recombinant Monoclonal ApoER2 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.
Low-density lipoprotein receptor-related protein 8, LRP-8, Apolipoprotein E receptor 2, LRP8, APOER2
IgG
Rabbit
Constituents: 100% PBS
Liquid
Monoclonal
Yes
EPR23779-154
Affinity purification Protein A
Blue Ice
+4°C
ab281138 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human LRP8. The recommended pair for sandwich ELISA is:
Capture: ab281138, Human LRP8 Capture Antibody (unconjugated)
Detector: ab280988, Human LRP8 Detector Antibody (unconjugated)
The reference range value is 31 - 4000 pg/mL.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.
This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.
ApoER2 contributes to neural processes like synaptic transmission and neuronal migration. It forms part of a protein complex with reelin a process essential for dendritic spine development and long-term potentiation. Its involvement in transporting cholesterol and other lipids is critical for maintaining neuronal function and integrity.
ApoER2 also known as apolipoprotein E receptor 2 or LRP8 is a member of the LDL receptor family weighing about 130 kDa. It is expressed mainly in the brain but also in the heart and other tissues. This receptor interacts with extracellular binding partners such as lipoproteins and reelin to mediate signal transduction across cell membranes. ApoER2 plays an important role in brain development and synaptic plasticity through these interactions.
ApoER2 participates in the reelin signaling pathway which is important for brain layer formation during development. It also interacts with other proteins like Disabled-1 (Dab1) to propagate signals initiated by reelin binding. This pathway also links ApoER2 to the regulation of synaptic strength and plasticity which are significant in learning and memory processes.
ApoER2 has connections to Alzheimer's disease and schizophrenia. Its interaction with amyloid-beta precursor protein (APP) in Alzheimer's disease impacts plaque formation and neuronal cell loss. In schizophrenia altered reelin-ApoER2 signaling can disrupt synaptic functions suggesting its involvement in the disorder's pathophysiology. Understanding these interactions may offer insights into potential therapeutic interventions.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Sandwich ELISA of ab253578 with the capture antibody ab281138 dilution at 2 µg/mL and detector antibody ab280988 dilution at 0.5 µg/mL.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com