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AB92273

Anti-APOL6 antibody

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(3 Publications)

Goat Polyclonal APOL6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human APOL6 aa 1-50.

View Alternative Names

UNQ3095/PRO21341, APOL6, Apolipoprotein L6, Apolipoprotein L-VI, ApoL-VI

1 Images
Western blot - Anti-APOL6 antibody (AB92273)
  • WB

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Western blot - Anti-APOL6 antibody (AB92273)

All lanes:

Western blot - Anti-APOL6 antibody (ab92273) at 3 µg/mL

All lanes:

Human kidney lysate in RIPA buffer at 35 µg

Predicted band size: 38 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human APOL6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9BWW8

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Proteins & Peptides

AB164299

Recombinant Human APOL6 protein

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-10 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APOL6 also known as apolipoprotein L6 is a protein with an approximate molecular mass of 41 kDa. Expressed primarily in the liver kidney and heart APOL6 plays a critical role in modulating lipid metabolism. As a member of the apolipoprotein L family APOL6 is involved in lipid binding and transport which are essential processes for maintaining lipid homeostasis in the cell.
Biological function summary

APOL6 influences important cellular processes such as apoptosis and lipid metabolic processes. Although not part of a large protein complex APOL6 contributes significantly to the regulation of phospholipid transport and stability within cellular membranes. Through these functions APOL6 supports cellular homeostasis and impacts the regulation of cell death pathways.

Pathways

Lipid metabolism and cell signaling heavily involve APOL6. It interacts with other apolipoproteins and factors like cholesterol transport proteins. Within the lipid metabolic pathway APOL6 facilitates proper lipid transport working closely with apolipoprotein E (ApoE) which is another key player in these processes. Disruption of this interaction can lead to imbalances in lipid homeostasis affecting overall health.

APOL6 has been linked to conditions like cardiovascular disease and specific forms of cancer. Its involvement in lipid metabolism and apoptosis suggests that alterations in APOL6 function or expression may lead to these health issues. APOL6 connects to proteins such as ApoE in cardiovascular diseases due to their shared roles in lipid transport and metabolism which directly affects plaque formation and cell health in blood vessels. Understanding these relationships helps in targeting therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
See full target information APOL6
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Medicine 104:e42406 PubMed40355224

2025

APOL6 as a potential biomarker of immuno-correlation and therapeutic prediction in cancer immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Jialin Yao,Wenyuan Gan,Jiukang Sun,Zhihang Han,Dongqing Li,Lei Cao,Lingjun Zhu

Angiogenesis 28:24 PubMed40266369

2025

ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage.

Applications

Unspecified application

Species

Unspecified reactive species

Bongnam Jung,Hitomi Yagi,Andrew Kuo,Tim F Dorweiler,Masanori Aikawa,Taku Kasai,Sasha A Singh,Andrew J Dannenberg,Zhongjie Fu,Colin Niaudet,Lois E H Smith,Timothy Hla

Biomolecules 13: PubMed36979348

2023

Upregulation of Apolipoprotein L6 Improves Tumor Immunotherapy by Inducing Immunogenic Cell Death.

Applications

Unspecified application

Species

Unspecified reactive species

Kecheng Liu,Yutong Chen,Bixiang Li,Yaning Li,Xinyue Liang,Hai Lin,Lisi Luo,Tianliang Chen,Yalan Dai,Wenzheng Pang,Linjuan Zeng
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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