AB31992

Anti-Apolipoprotein B antibody

(3 Reviews)

(14 Publications)

Rabbit Polyclonal Apolipoprotein B antibody. Suitable for ID, WB and reacts with Mouse, Human samples. Cited in 14 publications. Immunogen corresponding to Native Full Length Protein corresponding to Mouse Apob.

View Alternative Names

Apolipoprotein B-100, Apo B-100, APOB, Apolipoprotein B100

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, ID

applications

Immunogen

Native Full Length Protein corresponding to Mouse Apob.

E9Q414

Specificity

ab31992 recognizes Apolipoprotein B48 and B100, as these proteins are highly conserved.

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ID" : {"fullname" : "Immunodiffusion", "shortname":"ID"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ID-species-checked": "guaranteed", "ID-species-dilution-info": "", "ID-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "ID-species-checked": "guaranteed", "ID-species-dilution-info": "", "ID-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purity

Whole antiserum

Purification notes

ab31992 is a heat inactivated neat serum.

Storage buffer

Preservative: 0.05% Sodium azide Constituents: 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein B often referred to as ApoB is a core protein component of low-density lipoproteins (LDL) and is essential for their assembly and secretion. ApoB is also known as apolipoproteine B and apolipoprotein B protein. This protein has a large molecular weight approximately 550 kDa. ApoB is primarily expressed in the liver and to some extent in the intestine. Its large size allows it to provide structural integrity to lipoprotein particles playing a role in lipid metabolism.

Biological function summary

ApoB plays a significant role in lipid transport and metabolism. It is a critical component of the lipoprotein particle complex which is responsible for the transport of lipids such as cholesterol and triglycerides through the bloodstream. ApoB helps in the binding of lipoproteins to cell receptors facilitating the uptake of lipids by tissues. Its presence on the surface of lipoproteins makes it important for normal cholesterol homeostasis in the human body.

Pathways

ApoB is integrated within the lipid metabolism pathway. It interacts with proteins such as microsomal triglyceride transfer protein (MTP) during the assembly and secretion of lipoproteins. This pathway is essential for the normal transport of lipids throughout the body and influences processes like absorption of dietary fats. ApoB also plays a role in the pathways related to atherosclerosis where it influences the deposition of cholesterol in arterial walls.

ApoB is well-associated with cardiovascular diseases notably atherosclerosis and familial hypercholesterolemia. In these conditions elevated levels of ApoB correlate to an increased risk of plaque formation in blood vessels. ApoB in conjunction with LDL receptor and other related proteins influences lipid homeostasis and disorders where lipid oxidation or accumulation is present. Monitoring ApoB and its concentration can be vital for assessing cardiovascular disease risk.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

See full target information APOB

style

left-column

Publications (14)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 299:103022 PubMed36805337

2023

Fitm2 is required for ER homeostasis and normal function of murine liver.

Applications

Unspecified application

Species

Unspecified reactive species

Laura M Bond,Ayon Ibrahim,Zon W Lai,Rosemary L Walzem,Roderick T Bronson,Olga R Ilkayeva,Tobias C Walther,Robert V Farese

The Journal of clinical investigation 131: PubMed34779419

2021

TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Quiroz-Figueroa,Cecilia Vitali,Donna M Conlon,John S Millar,John W Tobias,Robert C Bauer,Nicholas J Hand,Daniel J Rader

Journal of cellular and molecular medicine 24:9945-9957 PubMed32666618

2020

An extracellular vesicle epitope profile is associated with acute myocardial infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Jacopo Burrello,Sara Bolis,Carolina Balbi,Alessio Burrello,Elena Provasi,Elena Caporali,Lorenzo Grazioli Gauthier,Andrea Peirone,Fabrizio D'Ascenzo,Silvia Monticone,Lucio Barile,Giuseppe Vassalli

Nutrients 12: PubMed32443556

2020

Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Po-An Hu,Chia-Hui Chen,Bei-Chia Guo,Yu Ru Kou,Tzong-Shyuan Lee

Journal of cell science 132: PubMed30559250

2019

Perilipin-2 is critical for efficient lipoprotein and hepatitis C virus particle production.

Applications

Unspecified application

Species

Unspecified reactive species

Susan Lassen,Cordula Grüttner,Van Nguyen-Dinh,Eva Herker

Scientific reports 8:3893 PubMed29497123

2018

Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Anja Schöbel,Kathrin Rösch,Eva Herker

Journal of cellular physiology 233:4770-4782 PubMed29150932

2018

High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Dongsheng Yu,Gang Chen,Minglin Pan,Jia Zhang,Wenping He,Yang Liu,Xue Nian,Liang Sheng,Bin Xu

Biochimica et biophysica acta. Molecular and cell 1863:323-338 PubMed29307784

2018

Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.

Applications

Unspecified application

Species

Unspecified reactive species

Sherrelle Milligan,Gregory G Martin,Danilo Landrock,Avery L McIntosh,John T Mackie,Friedhelm Schroeder,Ann B Kier

Lipids 52:385-397 PubMed28382456

2017

Effect of Fabp1/Scp-2/Scp-x Ablation on Whole Body and Hepatic Phenotype of Phytol-Fed Male Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Danilo Landrock,Sherrelle Milligan,Gregory G Martin,Avery L McIntosh,Kerstin K Landrock,Friedhelm Schroeder,Ann B Kier

Biochimica et biophysica acta. Molecular and cell biology of lipids 1862:291-304 PubMed27940000

2016

Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.

Applications

Unspecified application

Species

Unspecified reactive species

Sherrelle Milligan,Gregory G Martin,Danilo Landrock,Avery L McIntosh,John T Mackie,Friedhelm Schroeder,Ann B Kier

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Apolipoprotein B antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purity

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise