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AB239581

Anti-Apolipoprotein B antibody [C3]

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(1 Publication)

Mouse Monoclonal Apolipoprotein B antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Apob aa 3350-3550.

View Alternative Names

Aa1064, Ac1-060, Apob, Apolipoprotein B-100, Apo B-100, Apolipoprotein B100

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein B antibody [C3] (AB239581)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein B antibody [C3] (AB239581)

Paraffin-embedded rat skeletal muscle tissue stained for Apolipoprotein B using ab239581 at 30 μg/mL in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein B antibody [C3] (AB239581)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein B antibody [C3] (AB239581)

Paraffin-embedded rat liver tissue stained for Apolipoprotein B using ab239581 at 30 μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-Apolipoprotein B antibody [C3] (AB239581)
  • WB

Supplier Data

Western blot - Anti-Apolipoprotein B antibody [C3] (AB239581)

All lanes:

Western blot - Anti-Apolipoprotein B antibody [C3] (ab239581) at 1/100 dilution

All lanes:

Recombinant rat Apolipoprotein B protein

Predicted band size: 515 kDa

false

Western blot - Anti-Apolipoprotein B antibody [C3] (AB239581)
  • WB

Supplier Data

Western blot - Anti-Apolipoprotein B antibody [C3] (AB239581)

All lanes:

Western blot - Anti-Apolipoprotein B antibody [C3] (ab239581) at 5 µg/mL

All lanes:

Rat liver tissue lysate

Secondary

All lanes:

HRP-Linked Goat Anti-Mouse IgG Polyclonal Antibody at 0.2 µg/mL

Predicted band size: 515 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C3

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Rat Apob aa 3350-3550. The exact immunogen used to generate this antibody is proprietary information.

Q7TMA5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/400", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein B often referred to as ApoB is a core protein component of low-density lipoproteins (LDL) and is essential for their assembly and secretion. ApoB is also known as apolipoproteine B and apolipoprotein B protein. This protein has a large molecular weight approximately 550 kDa. ApoB is primarily expressed in the liver and to some extent in the intestine. Its large size allows it to provide structural integrity to lipoprotein particles playing a role in lipid metabolism.
Biological function summary

ApoB plays a significant role in lipid transport and metabolism. It is a critical component of the lipoprotein particle complex which is responsible for the transport of lipids such as cholesterol and triglycerides through the bloodstream. ApoB helps in the binding of lipoproteins to cell receptors facilitating the uptake of lipids by tissues. Its presence on the surface of lipoproteins makes it important for normal cholesterol homeostasis in the human body.

Pathways

ApoB is integrated within the lipid metabolism pathway. It interacts with proteins such as microsomal triglyceride transfer protein (MTP) during the assembly and secretion of lipoproteins. This pathway is essential for the normal transport of lipids throughout the body and influences processes like absorption of dietary fats. ApoB also plays a role in the pathways related to atherosclerosis where it influences the deposition of cholesterol in arterial walls.

ApoB is well-associated with cardiovascular diseases notably atherosclerosis and familial hypercholesterolemia. In these conditions elevated levels of ApoB correlate to an increased risk of plaque formation in blood vessels. ApoB in conjunction with LDL receptor and other related proteins influences lipid homeostasis and disorders where lipid oxidation or accumulation is present. Monitoring ApoB and its concentration can be vital for assessing cardiovascular disease risk.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
See full target information Apob
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic surgery and research 20:835 PubMed40999516

2025

Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4/Stat5b/NF-κB signaling to alleviate osteoarthritis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Daoliang Jiang,Xiaoli Xu,Wenjing Yang,Mengjia Tang,Yuping Zhang,Lingfeng Shi,Jiongyu Hu
View all publications
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