Anti-APPBP2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

APPBP2 is also known as amyloid precursor protein-binding protein 2 or PAT1. This protein has a molecular weight of roughly 135 kDa. APPBP2 acts as an adaptor molecule and plays a mechanical role in intracellular transport processes. It interacts directly with microtubule-associated proteins facilitating vesicular transport along the cytoskeletal network. APPBP2 expression is found prominently in the brain and lymphocytes hinting at its significance in these areas.

Biological function summary

APPBP2 contributes to cellular processes by involving itself in the regulation of protein transport. It is part of a larger protein complex which includes kinesins that mediates cargo movement within cells. This action influences various cellular functions including cell signaling and neurotransmitter release. Through its interactions APPBP2 can affect synaptic activity by modulating the trafficking of synaptic vesicles and other cargo pertinent to neuronal communication.

Pathways

APPBP2 engages with the Wnt signaling pathway and neuronal apoptosis pathway. APPBP2 demonstrates a regulatory role by interacting with proteins such as beta-catenin in the Wnt pathway. These interactions influence gene expression and cell proliferation. In neuronal apoptosis APPBP2 acts in coordination with amyloid precursor protein (APP) further dictating cell survival and neurodegeneration processes.

Associated diseases and disorders

APPBP2 has implications in Alzheimer's disease and lymphomas. In Alzheimer's disease APPBP2 affects the processing of amyloid precursor protein connecting it to the pathogenesis of amyloid plaques characteristic of this condition. In lymphomas altered expression levels of APPBP2 may interact with oncogenic proteins contributing to tumor progression. This involvement links APPBP2 to broader cellular pathways and emphasizes its role in pathological contexts.