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AB82110

Anti-Aprotinin antibody [35]

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(1 Publication)

Mouse Monoclonal Aprotinin antibody. Suitable for WB, I-ELISA and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Cow Pancreatic trypsin inhibitor.

View Alternative Names

Pancreatic trypsin inhibitor, Aprotinin, Basic protease inhibitor, BPI, BPTI

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

35

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Cow

Applications

I-ELISA, WB

applications

Immunogen

Native Full Length Protein corresponding to Cow Pancreatic trypsin inhibitor.

P00974

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IELISA" : {"fullname" : "Indirect ELISA", "shortname":"I-ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Cow": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aprotinin is a protein that works mechanically as a serine protease inhibitor blocking the activity of enzymes like trypsin and kallikrein. Researchers know it also by the names 'bovine pancreatic trypsin inhibitor' (BPTI) or Trasylol. Aprotinin has a molecular mass of approximately 6.5 kDa. It is expressed in bovine tissue and extracted from bovine lung which allows scientists to use it in various experimental and clinical applications.
Biological function summary

Aprotinin plays a role in controlling proteolytic processes by inhibiting enzymes that degrade proteins. This inhibition is important in reducing fibrinolysis where it prevents the breakdown of fibrin clots. As a single-chain polypeptide aprotinin does not function as part of a larger protein complex but rather exerts its effects by directly interacting with target proteases in the bloodstream and other biological fluids.

Pathways

Aprotinin plays an important role in the coagulation pathway maintaining hemostasis by inhibiting fibrinolysis. It directly interacts with proteins such as plasmin which is involved in the breakdown of blood clots. Additionally aprotinin impacts kallikrein-kinin systems a second pathway it is involved with affecting blood pressure regulation and inflammation.

Aprotinin is studied in conditions involving excessive bleeding like surgery-related hemorrhage due to its potential to control bleeding by slowing clot breakdown. Researchers also examine its use in inflammatory disorders since it affects pathways involving kallikreins. Although effective there are considerations of safety when using aprotinin as it has been linked to adverse outcomes in cardiovascular-associated conditions with proteins like kallikrein and plasmin playing roles in these processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
See full target information Pancreatic trypsin inhibitor
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of neurochemistry 115:1077-89 PubMed20854368

2010

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain.

Applications

WB, ELISA

Species

Unspecified reactive species, Unspecified reactive species

Berislav V Zlokovic,Rashid Deane,Abhay P Sagare,Robert D Bell,Ethan A Winkler
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