AB191061

Anti-AQP-6 antibody - C-terminal

Name: Anti-AQP-6 antibody - C-terminal (ab191061) | Abcam
Brand: Abcam Limited
SKU: AB191061
Price: 520 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(6 Publications)

Rabbit Polyclonal AQP-6 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human AQP6 aa 250 to C-terminus.

View Alternative Names

AQP2L, AQP6, Aquaporin-6, AQP-6, Aquaporin-2-like, Kidney-specific aquaporin, hKID

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP-6 antibody - C-terminal (AB191061)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP-6 antibody - C-terminal (AB191061)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung cancer tissue labeling AQP-6 with ab191061 at 1 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP-6 antibody - C-terminal (AB191061)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling AQP-6 with ab191061 at 1 μg/ml.

Supplier Data

Western blot - Anti-AQP-6 antibody - C-terminal (AB191061)

All lanes:

Western blot - Anti-AQP-6 antibody - C-terminal (ab191061) at 0.5 µg/mL

Lane 1:

U87 cell lysate

Lane 2:

COLO320 cell lysate

Lane 3:

MCF7 cell lysate

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human AQP6 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13520

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin-6 (AQP-6) is an integral membrane protein and part of the aquaporin family primarily involved in water transport across cell membranes. It weighs approximately 28 kilodaltons. Unlike other aquaporins AQP-6 also allows passage of anions making it unique in its function within the family. AQP-6 is expressed mainly in kidney tissues particularly in renal collecting ducts where it facilitates fluid balance and ion exchange.

Biological function summary

This protein plays a role in maintaining osmotic balance and modulating cell volume. AQP-6 interacts with other membrane proteins but it is not typically part of larger macromolecular complexes. Its activity contributes significantly to renal urine concentration influencing water reabsorption and ion transport in the kidneys. AQP-6 ion permeability distinguishes it from other aquaporins allowing it to assist in the rapid response to cellular pH changes and osmotic shifts.

Pathways

AQP-6 is involved in the renal water reabsorption and acid-base balance pathways. It interacts with proteins such as AQP-1 and AQP-2 which are also prominent in water transport systems. AQP-6 affects physiological processes governed by hormonal regulation responding to vasopressin to modify water reabsorption rates accordingly.

Abnormalities in AQP-6 function or expression can relate to conditions like nephrogenic diabetes insipidus and acid-base disturbances. Dysfunctional AQP-6 impacts water balance and pH regulation leading to potential kidney-related disorders. The protein's interaction with AQP-2 in water reabsorption processes suggests a possible compensatory mechanism in these pathological states.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.

See full target information AQP6

style

left-column

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

NPJ precision oncology 9:258 PubMed40707658

2025

Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiarui Liu,Yang Han,Tiange Lu,Dai Yuan,Kang Lu,Yiqing Cai,Xiangxiang Zhou,Xin Wang

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 282:2911-2920 PubMed39725698

2024

Morphological studies of labyrinthine tissue in patients affected with Meniere's disease and vestibular schwannoma following labyrinthectomy.

Applications

Unspecified application

Species

Unspecified reactive species

Ankit Ajmera,Nikeith John,Adrienne Morey,Nigel Biggs,Sean Flanagan,Peter Earls,Daniel Brown,Payal Mukherjee

Molecular medicine reports 26: PubMed36177915

2022

Expression of ICOS in the salivary glands of patients with primary Sjogren's syndrome and its molecular mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Yi Jin,Rui Zhao,Zhonghui Xue,Juan Ji

JOR spine 3:e1098 PubMed33015573

2020

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Abbie Binch,Joseph Snuggs,Christine L Le Maitre

Research in veterinary science 125:162-169 PubMed31233960

2019

Investigating cellular location of aquaporins in the bovine kidney. A new view on renal physiology in cattle.

Applications

Unspecified application

Species

Unspecified reactive species

Katarzyna Michałek,Marta Grabowska

JOR spine 2:e1049 PubMed31463463

2019

Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph W Snuggs,Rebecca E Day,Frances C Bach,Matthew T Conner,Rowena A D Bunning,Marianna A Tryfonidou,Christine L Le Maitre

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-AQP-6 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP-6 antibody - C-terminal (AB191061)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP-6 antibody - C-terminal (AB191061)

Western blot - Anti-AQP-6 antibody - C-terminal (AB191061)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise