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AB32826

Anti-Aquaporin 7 antibody

0

(1 Review)

|

(6 Publications)

Rabbit Polyclonal Aquaporin 7 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 6 publications.

View Alternative Names

Aquaporin-7, AQP-7, Aquaglyceroporin-7, Aqp7

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

Primary Antibodies

AB15123

Anti-Aquaporin 7 antibody

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Primary Antibodies

AB191056

Anti-Aquaporin 9/AQP-9 antibody - C-terminal

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Primary Antibodies

AB168387

Anti-Aquaporin 1 antibody [EPR11588(B)]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aquaporin 1 antibody [EPR11588(B)] (AB168387)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 7 (AQP7) sometimes referred to as AQPap is a protein channel that enables the transport of water and small molecules like glycerol across cell membranes. It has a molecular mass of approximately 28 kDa. This protein is widely expressed in adipose tissue kidney and testis where it facilitates critical cellular processes by regulating water and solute flow. The localization of AQP7 in these tissues highlights its key role in the body’s fluid management and metabolic regulation.
Biological function summary

AQP7 plays an important role in maintaining the balance of glycerol and water within cells which is essential for energy homeostasis. It does not function as part of a known complex but works as an individual tetrameric channel. In adipose tissue AQP7 facilitates the release of glycerol consequently affecting lipid metabolism and energy storage. This function contributes significantly to how organisms respond to energy demands and metabolic changes.

Pathways

AQP7 is critical in glycerol transport and lipid metabolism pathways impacting insulin signaling and glucose regulation. AQP7 is closely associated with proteins like adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) which regulate lipid breakdown and mobilization. The interplay between these proteins and AQP7 illustrates its importance in pathways that govern energy balance and metabolic flexibility affecting how cells use stored energy.

AQP7 has associations with metabolic conditions such as obesity and type 2 diabetes. Altered expression or functionality of AQP7 in adipose tissue can influence glycerol release and consequently lipid and glucose metabolism. Dysregulation of AQP7 may also impact metabolic processes by interacting with proteins involved in lipid metabolism like ATGL and HSL. These connections highlight the significance of AQP7 in understanding the molecular basis of metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea (PubMed : 9252401). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity).
See full target information Aquaporin-7
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 121:e2319682121 PubMed38319972

2024

Molecular basis for human aquaporin inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Huang,Hannah Åbacka,Carter J Wilson,Malene Lykke Wind,Michael Rűtzler,Anna Hagström-Andersson,Pontus Gourdon,Bert L de Groot,Raminta Venskutonytė,Karin Lindkvist-Petersson

FEBS open bio 13:2094-2107 PubMed37731227

2023

The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Huang,Hannah Åbacka,Daniel Varela,Raminta Venskutonytė,Lotta Happonen,Jonathan S Bogan,Pontus Gourdon,Mahmood R Amiry-Moghaddam,Ingmar André,Karin Lindkvist-Petersson

Nature communications 14:600 PubMed36737436

2023

Cryo-EM structure supports a role of AQP7 as a junction protein.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Huang,Raminta Venskutonytė,Rashmi B Prasad,Hamidreza Ardalani,Sofia W de Maré,Xiao Fan,Ping Li,Peter Spégel,Nieng Yan,Pontus Gourdon,Isabella Artner,Karin Lindkvist-Petersson

Reproduction in domestic animals = Zuchthygiene 57 Suppl 5:78-81 PubMed35467055

2022

Changes in aquaporins mRNA expression and liquid storage at 17°C: A potential biomarker of boar sperm quality?

Applications

Unspecified application

Species

Unspecified reactive species

Marina Castany Quintana,Jaume Gardela,Mateo Ruiz-Conca,Manel López-Béjar,Cristina A Martinez,Heriberto Rodríguez-Martinez,Manuel Álvarez-Rodríguez

British journal of pharmacology 179:4092-4106 PubMed35366004

2022

Cholecystokinin promotes functional expression of the aquaglycerol channel aquaporin 7 in adipocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Adrian Plaza,Beatriz Merino,Mariano Ruiz-Gayo

Endocrinology 150:5181-90 PubMed19797117

2009

Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice.

Applications

WB

Species

Mouse

Ericka Diallo-Krou,Jingcheng Yu,Lesley A Colby,Ken Inoki,John E Wilkinson,Dafydd G Thomas,Thomas J Giordano,Ronald J Koenig
View all publications
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Product promise

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