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AB15129

Anti-Aquaporin 9/AQP-9 antibody

0

(1 Review)

|

(7 Publications)

Chicken Polyclonal Aquaporin 9/AQP-9 antibody. Suitable for ELISA and reacts with Rat samples. Cited in 7 publications.

View Alternative Names

Aqp9l, Aqp9, Aquaporin-9, AQP-9, Aquaglyceroporin-9

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

No

Reacts with

Rat

Applications

ELISA

applications

Immunogen

Synthetic Peptide within Rat Aquaporin-9. The exact immunogen used to generate this antibody is proprietary information.

P56627

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Reactivity data

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Product details

The control peptide, because of its low MW (<3kD), is not suitable for Western blotting. It should be used for ELISA or antibody blocking to confirm antibody specificity. We recommend the use of 0.5-1% milk in all primary/secondary antibody-enzyme conjugate incubations in order to suppress non-specific bands.
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 9 (AQP-9) also known as AQP9 or AQP is a member of the aquaporin family which functions as a water channel protein. The mass of AQP-9 is approximately 33 kDa. Expressed in the liver leukocytes and the male reproductive tract it facilitates the transport of water and some small solutes such as glycerol and urea across cellular membranes. This channel activity is essential for various physiological processes that require efficient fluid balance and solute exchange.
Biological function summary

This protein is integral to maintaining cellular and tissue homeostasis. AQP-9 does not operate alone but rather integrates within a broader network influencing metabolism and osmoregulation. It plays a critical role in hepatic glycerol uptake impacting both gluconeogenesis and lipogenesis processes. Its presence in immune cells like leukocytes suggests a role in immune responses potentially affecting the movement of immune cells and response to inflammation.

Pathways

Aquaporin 9 participates actively in both glycerol and water transport processes important for metabolic and osmoregulatory pathways. It is closely linked to the glycerol kinase pathway in the liver which affects energy balance and metabolic homeostasis. Within these pathways AQP-9 interrelates with other proteins such as aquaglyceroporins. Specifically it works alongside glycerol transport-related proteins to facilitate the balance of energy substrates contributing to different metabolic states in the body.

Aquaporin 9 is associated with insulin resistance and inflammation. Its altered expression or function may contribute to metabolic disorders like type 2 diabetes where dysregulated glycerol metabolism is observed. In the context of immune-related disorders changes in AQP-9 function can influence immune cell behavior and cytokine production linking it indirectly to pro-inflammatory states. Protein interplays during these conditions can include cytokines and other metabolic signaling proteins which further influence disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed : 10205677, PubMed : 9733774). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed : 9733774). AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed : 11972053). It is also permeable to H2O2 in vivo (By similarity). Could also be permeable to ammonium (PubMed : 15988592).
See full target information Aquaporin-9
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Molecular neurobiology 57:4530-4548 PubMed32748371

2020

Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival.

Applications

Unspecified application

Species

Unspecified reactive species

Sotaro Mori,Takuji Kurimoto,Akiko Miki,Hidetaka Maeda,Sentaro Kusuhara,Makoto Nakamura

Aging 12:1527-1544 PubMed31969493

2020

Aquaporin 9 inhibits growth and metastasis of hepatocellular carcinoma cells via Wnt/β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shengtao Liao,Hongyu Chen,Min Liu,Li Gan,Chuanfei Li,Wenguang Zhang,Lin Lv,Zhechuan Mei

Molecular medicine reports 21:291-303 PubMed31746418

2019

LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models.

Applications

Unspecified application

Species

Unspecified reactive species

Jianping Wu,Chuanguang Wang,Haiyang Ding

Heart and vessels 34:2041-2051 PubMed31218464

2019

Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingmei Huang,Xiaobin Yu,Hongxia Li,Lianhua Han,Xiangjun Yang

Molecular medicine reports 18:4987-4993 PubMed30320400

2018

The possible association between AQP9 in the intestinal epithelium and acute liver injury‑induced intestinal epithelium damage.

Applications

Unspecified application

Species

Unspecified reactive species

Tianxin Xiang,Shanfei Ge,Jiangxiong Wen,Junfeng Xie,Lixia Yang,Xiaoping Wu,Na Cheng

Cell 167:1511-1524.e10 PubMed27884405

2016

Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wenqiang Ma,Shihua Li,Shuoqian Ma,Lina Jia,Fuchun Zhang,Yong Zhang,Jingyuan Zhang,Gary Wong,Shanshan Zhang,Xuancheng Lu,Mei Liu,Jinghua Yan,Wei Li,Chuan Qin,Daishu Han,Chengfeng Qin,Na Wang,Xiangdong Li,George Fu Gao

The EMBO journal 25:4131-41 PubMed16932748

2006

Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Rodrigo Blomqvist,Hilmar Vidarsson,Olle Söder,Sven Enerbäck
View all publications
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