AB191056

Anti-Aquaporin 9/AQP-9 antibody - C-terminal

Name: Anti-Aquaporin 9/AQP-9 antibody - C-terminal (ab191056) | Abcam
Brand: Abcam Limited
SKU: AB191056

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(3 Publications)

Rabbit Polyclonal Aquaporin 9/AQP-9 antibody. C-terminal. Suitable for WB and reacts with Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Mouse Aquaporin-9 aa 250 to C-terminus.

View Alternative Names

Aquaporin-9, AQP-9, Aquaglyceroporin-9, Aqp9

1 Images

Supplier Data

Western blot - Anti-Aquaporin 9/AQP-9 antibody - C-terminal (AB191056)

All lanes:

Western blot - Anti-Aquaporin 9/AQP-9 antibody - C-terminal (ab191056) at 0.5 µg/mL

Lane 1:

Mouse liver tissue lysate

Lane 2:

Mouse lung tissue lysate

Lane 3:

Mouse spleen tissue lysate

Lane 4:

Mouse testis tissue lysate

Lane 5:

PC12 cell lysate

Lane 6:

NIH3T3 cell lysate

Lane 7:

HEPA cell lysate

Predicted band size: 31 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

applications

Immunogen

Synthetic Peptide within Mouse Aquaporin-9 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9JJJ3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 9 (AQP-9) also known as AQP9 or AQP is a member of the aquaporin family which functions as a water channel protein. The mass of AQP-9 is approximately 33 kDa. Expressed in the liver leukocytes and the male reproductive tract it facilitates the transport of water and some small solutes such as glycerol and urea across cellular membranes. This channel activity is essential for various physiological processes that require efficient fluid balance and solute exchange.

Biological function summary

This protein is integral to maintaining cellular and tissue homeostasis. AQP-9 does not operate alone but rather integrates within a broader network influencing metabolism and osmoregulation. It plays a critical role in hepatic glycerol uptake impacting both gluconeogenesis and lipogenesis processes. Its presence in immune cells like leukocytes suggests a role in immune responses potentially affecting the movement of immune cells and response to inflammation.

Pathways

Aquaporin 9 participates actively in both glycerol and water transport processes important for metabolic and osmoregulatory pathways. It is closely linked to the glycerol kinase pathway in the liver which affects energy balance and metabolic homeostasis. Within these pathways AQP-9 interrelates with other proteins such as aquaglyceroporins. Specifically it works alongside glycerol transport-related proteins to facilitate the balance of energy substrates contributing to different metabolic states in the body.

Aquaporin 9 is associated with insulin resistance and inflammation. Its altered expression or function may contribute to metabolic disorders like type 2 diabetes where dysregulated glycerol metabolism is observed. In the context of immune-related disorders changes in AQP-9 function can influence immune cell behavior and cytokine production linking it indirectly to pro-inflammatory states. Protein interplays during these conditions can include cytokines and other metabolic signaling proteins which further influence disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed : 22081610). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (PubMed : 17360690, PubMed : 22081610). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (By similarity). AQP9 may also facilitate hepatic urea extrusion (PubMed : 22081610, PubMed : 23042941). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed : 32748371). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed : 11972053, PubMed : 19805235). It is also permeable to H2O2 in vivo (PubMed : 26837049). Could also be permeable to ammonium (By similarity).

See full target information Aquaporin-9

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40004131

2025

Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Yiling Bai,Zhaojia Wu,Scot C Leary,Chen Fang,Michelle Yu,Harald Genth,Yufeng Xie,Jinhui Shi,Jim Xiang

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23170 PubMed37676718

2023

ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Shuxin Li,Jianyi Lv,Xing Zhang,Qiuyu Zhang,Zhihui Li,Jing Lu,Xueyun Huo,Meng Guo,Xin Liu,Ran Gao,Jianan Gong,Changlong Li,Weiying Li,Tongmei Zhang,Jinghui Wang,Zhenwen Chen,Xiaoyan Du

Heart and vessels 34:2041-2051 PubMed31218464

2019

Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingmei Huang,Xiaobin Yu,Hongxia Li,Lianhua Han,Xiangjun Yang

View all publications

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Product promise

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Anti-Aquaporin 9/AQP-9 antibody - C-terminal

Western blot - Anti-Aquaporin 9/AQP-9 antibody - C-terminal (AB191056)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

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Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise