Rabbit Polyclonal Aquaporin 9/AQP-9 antibody. C-terminal. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Aquaporin-9 aa 250 to C-terminus.
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- Heart and vessels 34:2041-20512019Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXingmei Huang et. al.PubMed 31218464
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Mouse Aquaporin-9 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9JJJ3
Reactivity data
Select an application| WB | |
|---|---|
| Mouse | Tested |
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 0.10000-0.50000 µg/mL | Notes - |
Species Rat | Dilution info 0.10000-0.50000 µg/mL | Notes - |
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Target data
Function
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:22081610). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (PubMed:17360690, PubMed:22081610). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (By similarity). AQP9 may also facilitate hepatic urea extrusion (PubMed:22081610, PubMed:23042941). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:32748371). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:11972053, PubMed:19805235). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity).
Alternative names
Aquaporin-9, AQP-9, Aquaglyceroporin-9, Aqp9
Recommended products
Rabbit Polyclonal Aquaporin 9/AQP-9 antibody. C-terminal. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Aquaporin-9 aa 250 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Aquaporin-9 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9JJJ3
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Aquaporin 9 (AQP-9) also known as AQP9 or AQP is a member of the aquaporin family which functions as a water channel protein. The mass of AQP-9 is approximately 33 kDa. Expressed in the liver leukocytes and the male reproductive tract it facilitates the transport of water and some small solutes such as glycerol and urea across cellular membranes. This channel activity is essential for various physiological processes that require efficient fluid balance and solute exchange.
- Biological function summary
This protein is integral to maintaining cellular and tissue homeostasis. AQP-9 does not operate alone but rather integrates within a broader network influencing metabolism and osmoregulation. It plays a critical role in hepatic glycerol uptake impacting both gluconeogenesis and lipogenesis processes. Its presence in immune cells like leukocytes suggests a role in immune responses potentially affecting the movement of immune cells and response to inflammation.
- Pathways
Aquaporin 9 participates actively in both glycerol and water transport processes important for metabolic and osmoregulatory pathways. It is closely linked to the glycerol kinase pathway in the liver which affects energy balance and metabolic homeostasis. Within these pathways AQP-9 interrelates with other proteins such as aquaglyceroporins. Specifically it works alongside glycerol transport-related proteins to facilitate the balance of energy substrates contributing to different metabolic states in the body.
- Associated diseases and disorders
Aquaporin 9 is associated with insulin resistance and inflammation. Its altered expression or function may contribute to metabolic disorders like type 2 diabetes where dysregulated glycerol metabolism is observed. In the context of immune-related disorders changes in AQP-9 function can influence immune cell behavior and cytokine production linking it indirectly to pro-inflammatory states. Protein interplays during these conditions can include cytokines and other metabolic signaling proteins which further influence disease progression.
Product promise
Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Aquaporin 9/AQP-9 antibody - C-terminal (ab191056)
All lanes: Western blot - Anti-Aquaporin 9/AQP-9 antibody - C-terminal (ab191056) at 0.5 µg/mL
Lane 1: Mouse liver tissue lysate
Lane 2: Mouse lung tissue lysate
Lane 3: Mouse spleen tissue lysate
Lane 4: Mouse testis tissue lysate
Lane 5: PC12 cell lysate
Lane 6: NIH3T3 cell lysate
Lane 7: HEPA cell lysate
Predicted band size: 31 kDa
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