Anti-ARD1A antibody [3G3B9]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ARD1A also known as NAA10 is a catalytic subunit of the N-terminal acetyltransferase complex. This protein has a mass of approximately 25 kDa. It acetylates the alpha-amino group of nascent polypeptides which affects stability localization and function of proteins. ARD1A is expressed in various tissues including heart skeletal muscle and liver. Its enzymatic activity requires a partnership with NAA15 another subunit which together form the N-terminal acetyltransferase A (NatA) complex.

Biological function summary

Acetylation by ARD1A modulates protein interactions and function. The NatA complex where ARD1A acts influences processes including cell cycle regulation and apoptosis. By modifying substrates critical for cell fate ARD1A plays a role in maintaining cellular balance. This complex helps in modifying proteins like actin which regulates the cytoskeleton a cellular structure essential for movement and division.

Pathways

Protein acetylation by ARD1A fits into the cellular signaling and protein degradation pathways. The complex alters substrates involved in proteasome-mediated degradation relating it to ubiquitin-proteasome pathways. Other interactions include the modulation of gene expression pathways impacting proteins like histones which are core to chromatin structure and gene regulation.

Associated diseases and disorders

Improper ARD1A function can relate to cancer and neurodegenerative diseases. Alterations in ARD1A activity have connected it to tumorigenesis due to its role in cell growth regulation. Additionally decreased N-terminal acetylation by ARD1A has shown a link to neurodegeneration. This happens as it affects proteins such as tau which is significant in Alzheimer's disease when improperly modified.