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AB243713

Anti-ARHGAP11A antibody

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(3 Publications)

Rabbit Polyclonal ARHGAP11A antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP11A aa 400-500.

View Alternative Names

KIAA0013, ARHGAP11A, Rho GTPase-activating protein 11A, Rho-type GTPase-activating protein 11A

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP11A antibody (AB243713)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP11A antibody (AB243713)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for ARHGAP11A (green) using ab243713 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ARHGAP11A aa 400-500. The exact immunogen used to generate this antibody is proprietary information.

Q6P4F7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARHGAP11A also known as Rho GTPase-activating protein 11A mainly functions as a Rho GTPase-activating protein. It influences the Rho family of small GTPases by converting them from an active GTP-bound state to an inactive GDP-bound state. This protein has an approximate mass of 102 kDa. Human tissues such as the brain and testes highly express ARHGAP11A while other tissues show lower expression levels.
Biological function summary

ARHGAP11A plays a role in cell division and cytoskeletal organization by interacting with Rho GTPases. It operates as part of regulatory networks affecting cytoskeletal dynamics essential for cellular shape and motility. Studies suggest that it may form complexes with other proteins that modulate actin filament assembly thereby aiding in processes like cell migration and mitotic spindle formation.

Pathways

ARHGAP11A influences cellular pathways that involve cytoskeletal reorganization and cell cycle regulation. The Rho signaling pathway involves ARHGAP11A controlling actin cytoskeleton reformation. It interacts with other proteins like RhoA influencing signal transduction processes. The precise modulation of cytoskeletal signaling indicates ARHGAP11A’s critical role in various cellular activities.

ARHGAP11A associates with neurodevelopmental disorders due to its expression in brain tissues implicating it in brain development processes. Aberrations in its regulation may contribute to cancer progression via dysregulation of cell migration and invasion pathways. Connections with other proteins like RhoA link ARHGAP11A to these disorders underpinning its involvement in disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
See full target information ARHGAP11A
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

BioFactors (Oxford, England) 51:e2141 PubMed39482272

2024

Machine learning models reveal ARHGAP11A's impact on lymph node metastasis and stemness in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoli Wang,Yan Zhou,Xiaomin Lu,Lili Shao

Science advances 9:eadg2339 PubMed37352355

2023

VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqiang Hu,Yingchao Xie,Jiansen Lu,Jianwu Yang,Jiahuan Zhang,Huaji Jiang,Hongyu Li,Yufeng Zhang,Dan Wu,Ke Zeng,Xiaochun Bai,Xiao Yu

Frontiers in surgery 9:857170 PubMed35495761

2022

Involvement of MiRNA-211-5p and Arhgap11a Interaction During Osteogenic Differentiation of MC3T3-E1 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Ju,Guangfeng Zhang,Xu Zhang,Jingting Wang,Tong Wu,Huafeng Li
View all publications
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