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AB121617

Anti-ARHGAP23 antibody

4

(1 Review)

|

(1 Publication)

Rabbit Polyclonal ARHGAP23 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP23 aa 500-600.

View Alternative Names

KIAA1501, ARHGAP23, Rho GTPase-activating protein 23, Rho-type GTPase-activating protein 23

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP23 antibody (AB121617)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP23 antibody (AB121617)

Immunofluorescent staining of Human cell line U-251MG shows positivity in nucleus but not nucleoli and plasma membrane. Recommended concentration of ab121617 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ARHGAP23 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.

Q9P227

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARHGAP23 also known as Rho GTPase-activating protein 23 is a member of the RhoGAP family of proteins. It plays an important role in regulating Rho protein signaling by converting active GTP-bound Rho proteins into their inactive GDP-bound state. The molecular mass of ARHGAP23 is approximately 183 kDa. It is mainly expressed in various tissues including the brain and liver indicating its important role in cellular activities across different organ systems.
Biological function summary

ARHGAP23 acts as a critical regulator of cytoskeletal dynamics and cellular morphology. It functions as part of a complex that modulates actin filament organization which is essential for cell movement and proliferation. Through its interactions it influences the cellular response to external stimuli impacting processes such as cell migration and adhesion which are important in tissue development and repair.

Pathways

ARHGAP23 is a significant component of the Rho signaling pathway where it works to control cytoskeletal rearrangements. It interacts with other proteins like RhoA and Cdc42 coordinating their activity to ensure precise regulation of cytoskeletal structures. Additionally its involvement in the signaling cascade affects the MAPK pathway with implications for cellular growth and differentiation.

ARHGAP23 alterations can be associated with certain types of cancers and neurodegenerative disorders. Changes in its expression or function can disrupt normal cell-cell adhesion and cytoskeletal organization contributing to the progression of malignant tumors. In the context of neurodegeneration its interaction with proteins like Rac1 may influence neuronal survival and function potentially linking it to disorders such as Alzheimer's disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
See full target information ARHGAP23
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cardiothoracic surgery 20:51 PubMed39780196

2025

SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1.

Applications

Unspecified application

Species

Unspecified reactive species

Xinjie Fan,Qichu Zhu,Chengzhuo Du,Jinlai Chen,Yingming Su
View all publications
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