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Rabbit Polyclonal ARHGAP9 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Rho GTPase-activating protein 9 aa 50-300.

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Images

Western blot - Anti-ARHGAP9 antibody (AB101361), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Rho GTPase-activating protein 9 aa 50-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BRR9

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Target data

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Alternative names

Recommended products

Rabbit Polyclonal ARHGAP9 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Rho GTPase-activating protein 9 aa 50-300.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Rho GTPase-activating protein 9 aa 50-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BRR9
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ARHGAP9 also known as Rho GTPase activating protein 9 functions mainly as a GTPase-activating protein. It acts to regulate the Rho family of GTPases by accelerating their intrinsic GTPase activity leading to the inactivation of Rho proteins. ARHGAP9 is approximately 92 kDa in mass. Its expression is noted predominantly in hematopoietic tissues like the spleen and the lymph nodes suggesting its involvement in immune cell regulation.

Biological function summary

ARHGAP9 modulates cytoskeletal dynamics and cell movement influencing various cellular behaviors such as cell polarity migration and adhesion. The protein participates in the regulation of cell morphology and motility by affecting actin cytoskeleton organization. Although not a part of a specific complex ARHGAP9 interacts closely with other cytoskeletal regulators to execute these functions.

Pathways

ARHGAP9 engages significantly in the Rho GTPase signaling pathway influencing chemotaxis and actin filament reorganization. This interaction ties it with other related proteins like Rac1 and Cdc42 which play roles in modulating cell structure and movement. Additionally ARHGAP9 contributes to the modulation of the MAPK (Mitogen-Activated Protein Kinase) signaling pathway which impacts cell proliferation and differentiation processes.

Associated diseases and disorders

Those affected by abnormal ARHGAP9 activity often include cancer and immune-related conditions. Abnormal regulation of ARHGAP9 can disrupt normal cell movement and proliferation leading to cancer progression and metastasis. In immune disorders its dysregulation may influence inflammatory responses and leukocyte function. Connections with other proteins such as RhoA and Rac1 are important in understanding its role in these disease contexts as they together affect pathways involved in cell survival and immune cell activity.

Product promise

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1 product image

  • Western blot - Anti-ARHGAP9 antibody (ab101361), expandable thumbnail

    Western blot - Anti-ARHGAP9 antibody (ab101361)

    7.5% SDS-PAGE

    All lanes: Western blot - Anti-ARHGAP9 antibody (ab101361) at 1/2000 dilution

    All lanes: Raji cell lysate at 30 µg

    Predicted band size: 83 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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