Rabbit Polyclonal ARHGAP9 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Rho GTPase-activating protein 9 aa 50-300.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Rho GTPase-activating protein 9, Rho-type GTPase-activating protein 9, ARHGAP9
Rabbit Polyclonal ARHGAP9 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Rho GTPase-activating protein 9 aa 50-300.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP9 also known as Rho GTPase activating protein 9 functions mainly as a GTPase-activating protein. It acts to regulate the Rho family of GTPases by accelerating their intrinsic GTPase activity leading to the inactivation of Rho proteins. ARHGAP9 is approximately 92 kDa in mass. Its expression is noted predominantly in hematopoietic tissues like the spleen and the lymph nodes suggesting its involvement in immune cell regulation.
ARHGAP9 modulates cytoskeletal dynamics and cell movement influencing various cellular behaviors such as cell polarity migration and adhesion. The protein participates in the regulation of cell morphology and motility by affecting actin cytoskeleton organization. Although not a part of a specific complex ARHGAP9 interacts closely with other cytoskeletal regulators to execute these functions.
ARHGAP9 engages significantly in the Rho GTPase signaling pathway influencing chemotaxis and actin filament reorganization. This interaction ties it with other related proteins like Rac1 and Cdc42 which play roles in modulating cell structure and movement. Additionally ARHGAP9 contributes to the modulation of the MAPK (Mitogen-Activated Protein Kinase) signaling pathway which impacts cell proliferation and differentiation processes.
Those affected by abnormal ARHGAP9 activity often include cancer and immune-related conditions. Abnormal regulation of ARHGAP9 can disrupt normal cell movement and proliferation leading to cancer progression and metastasis. In immune disorders its dysregulation may influence inflammatory responses and leukocyte function. Connections with other proteins such as RhoA and Rac1 are important in understanding its role in these disease contexts as they together affect pathways involved in cell survival and immune cell activity.
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7.5% SDS-PAGE
All lanes: Western blot - Anti-ARHGAP9 antibody (ab101361) at 1/2000 dilution
All lanes: Raji cell lysate at 30 µg
Predicted band size: 83 kDa
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