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AB220238

Anti-ARIP4 antibody

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(1 Publication)

Rabbit Polyclonal ARIP4 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RAD54L2 aa 1250-1400.

View Alternative Names

ARIP4, KIAA0809, RAD54L2, Helicase ARIP4, Androgen receptor-interacting protein 4, RAD54-like protein 2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ARIP4 antibody (AB220238)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ARIP4 antibody (AB220238)

Immunofluorescent analysis of U-2 OS cells (PFA-fixed/Triton X-100 permeabilized) labeling ARIP4 with ab220238 at 4μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RAD54L2 aa 1250-1400. The exact immunogen used to generate this antibody is proprietary information.

Q9Y4B4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARIP4 also known as androgen receptor-interacting protein 4 or RAD54-like homolog 1 functions as an ATP-dependent chromatin-remodeling enzyme. Its molecular mass is approximately 150 kDa. ARIP4 tightly associates with chromatin structures and resides in the nucleus. This protein expresses mainly in tissues like the prostate and testis suggesting a specialized role in these locations.
Biological function summary

ARIP4 participates in the modulation of androgen receptor (AR) activity. It serves as an important part of the chromatin remodeling complex altering chromatin architecture to regulate transcription. This interaction significantly impacts gene expression linked to androgen response elements (AREs). ARIP4 helps unwind DNA allowing access to transcriptional machinery and influencing steroid hormone responses.

Pathways

ARIP4 plays a role in androgen signaling and DNA repair pathways. It interacts with androgen receptors facilitating gene transcription in response to androgen hormones. Additionally ARIP4 associates with components like RAD54L involved in homologous recombination repair contributing to DNA integrity maintenance. These pathways emphasize its roles in managing cellular response to hormones and genetic stability.

ARIP4's function impacts prostate cancer and androgen insensitivity syndrome. In prostate cancer its ability to modulate AR activity influences tumor progression and resistance to therapy. Dysregulation of ARIP4 contributes to maladaptive gene expression driving cancerous growth. In androgen insensitivity syndrome impaired ARIP4 function leads to inadequate androgen receptor activation disrupting normal male sexual development. ARIP4's interaction with AR is relevant in the pathogenesis of these conditions highlighting its potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).
See full target information RAD54L2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 25:105620 PubMed36465115

2022

TWIK-related acid-sensitive K channel 2 promotes renal fibrosis by inducing cell-cycle arrest.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Zhang,Jing Chen,Yufei Lu,Yan Yang,Weize Chen,Bo Shen,Jiachang Hu,Ping Jia,Sujuan Xu,Yiqin Shi,Yichun Ning,Jialin Wang,Yi Fang,Shuan Zhao,Yang Li,Yan Dai,Xiaoyan Zhang,Meng Xiang,Yang Tian,Zhichao Liu,Nana Song,Xiaoqiang Ding
View all publications
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