Anti-ARIP4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ARIP4 also known as androgen receptor-interacting protein 4 or RAD54-like homolog 1 functions as an ATP-dependent chromatin-remodeling enzyme. Its molecular mass is approximately 150 kDa. ARIP4 tightly associates with chromatin structures and resides in the nucleus. This protein expresses mainly in tissues like the prostate and testis suggesting a specialized role in these locations.

Biological function summary

ARIP4 participates in the modulation of androgen receptor (AR) activity. It serves as an important part of the chromatin remodeling complex altering chromatin architecture to regulate transcription. This interaction significantly impacts gene expression linked to androgen response elements (AREs). ARIP4 helps unwind DNA allowing access to transcriptional machinery and influencing steroid hormone responses.

Pathways

ARIP4 plays a role in androgen signaling and DNA repair pathways. It interacts with androgen receptors facilitating gene transcription in response to androgen hormones. Additionally ARIP4 associates with components like RAD54L involved in homologous recombination repair contributing to DNA integrity maintenance. These pathways emphasize its roles in managing cellular response to hormones and genetic stability.

Associated diseases and disorders

ARIP4's function impacts prostate cancer and androgen insensitivity syndrome. In prostate cancer its ability to modulate AR activity influences tumor progression and resistance to therapy. Dysregulation of ARIP4 contributes to maladaptive gene expression driving cancerous growth. In androgen insensitivity syndrome impaired ARIP4 function leads to inadequate androgen receptor activation disrupting normal male sexual development. ARIP4's interaction with AR is relevant in the pathogenesis of these conditions highlighting its potential as a therapeutic target.