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AB106441

Anti-ARL15 antibody

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(1 Publication)

Rabbit Polyclonal ARL15 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARL15.

View Alternative Names

ARFRP2, ARL15, ADP-ribosylation factor-like protein 15, ADP-ribosylation factor-related protein 2, ARF-related protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARL15 antibody (AB106441)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARL15 antibody (AB106441)

ab106441, at 5 ug/ml, staining ARL15 in Human spleen tissue by immunohistochemistry.

Western blot - Anti-ARL15 antibody (AB106441)
  • WB

Unknown

Western blot - Anti-ARL15 antibody (AB106441)

All lanes:

Western blot - Anti-ARL15 antibody (ab106441) at 1 µg/mL

All lanes:

K562 cell lysate at 15 µg

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ARL15. The exact immunogen used to generate this antibody is proprietary information.

Q9NXU5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL15 also known as ADP-ribosylation factor-like protein 15 is a member of the ARF family of GTPases. This small GTP-binding protein weighs about 21 kDa. ARL15 resides mainly in the cytoplasm but its expression is also notable in adipose tissue and the pancreas. Mechanical interaction of ARL15 with membranes and other molecules is characteristic for proteins in the ARF family indicating a role in cellular functions that involve vesicle trafficking or membrane remodeling.
Biological function summary

ARL15 influences metabolic processes and signaling pathways. It integrates into multiprotein complexes that regulate various cellular activities. Research suggests its involvement in lipid metabolism and adipogenesis playing a role in the regulation of insulin sensitivity. These biological functions make ARL15 significant for maintaining cellular energy balance and metabolic homeostasis.

Pathways

ARL15 engages with two central pathways: the insulin signaling pathway and lipid metabolism. It influences these pathways by interacting with key proteins such as IRS1 in insulin signaling which impacts glucose uptake and energy regulation. Additionally in lipid metabolism ARL15 associates with proteins that control fatty acid oxidation and storage contributing to the overall lipid balance within the cell.

ARL15 has connections to type 2 diabetes and obesity. People with altered expression levels of ARL15 often exhibit changes in insulin sensitivity linking it to the pathophysiology of type 2 diabetes. ARL15 also interacts with PPARγ a protein highly involved in fat tissue development and implicated in obesity. These interactions indicate potential pathways through which ARL15 influences metabolic conditions making it a target of interest for disease research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ARL15
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 297:100948 PubMed34252459

2021

Recognition of lipoproteins by scavenger receptor class A members.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Cheng,Enlin Zheng,Bowen Yu,Ze Zhang,Yuanyuan Wang,Yingbin Liu,Yongning He
View all publications
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Product promise

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