Anti-ARPC1B antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ARPC1B also known as Actin-related protein 2/3 complex subunit 1B weighs around 41 kDa. This protein forms a part of the Arp2/3 complex which is instrumental in actin filament branching and growth. Researchers have detected ARPC1B expression in various tissues including blood cells and the skin highlighting its diverse functional roles in different cell types.

Biological function summary

ARPC1B contributes significantly to cell movement and shape maintenance. The protein acts as a component of the Arp2/3 complex which always requires additional nucleation factors to perform its function. This complex drives the reorganization of the actin cytoskeleton influencing cellular processes like migration and phagocytosis. It modulates the interaction of actin with branching networks thereby ensuring dynamic cellular adaptability to different environments.

Pathways

ARPC1B plays a critical role in the regulation of actin cytoskeleton and focal adhesion pathways. Scientists have associated ARPC1B with the WASP and WAVE proteins which stimulate actin assembly. These interactions enable ARPC1B to facilitate precise signaling pathways important for cell migration and immune responses. The protein’s participation in these pathways illustrates its key function in maintaining cytoskeletal integrity and cellular communication.

Associated diseases and disorders

ARPC1B has connections to severe combined immunodeficiency and Wiskott-Aldrich syndrome. These conditions often manifest through mutations affecting the actin cytoskeleton. ARPC1B’s relationship with the WASP protein highlights its involvement in regulating immune cell function and signaling. For individuals with deficiencies in ARPC1B these immune complications underline the importance of understanding its function in therapeutic contexts.