Rabbit Polyclonal ARPC5/p16 ARC antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 18 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARPC5 aa 1 to C-terminus.
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- World journal of gastrointestinal oncology 15:1567-15942023Cellular senescence throws new insights into patient classification and pharmacological interventions for clinical management of hepatocellular carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHou-Hong Wang,Wen-Li Chen,Ya-Yun Cui,Hui-Hui Gong,Heng LiPubMed 37746655
- Journal of medical virology 95:e284802023Single-cell transcriptomics dissects epithelial heterogeneity in HPV cervical adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCong Wang,Lei Li,Fuhao Wang,Xia Li,Jujie Sun,Xiaohui Li,Tianyu Lei,Qingyu Huang,Guangyu Zhang,Hongqing Wang,Dapeng Li,Jue Jia,Chunyan Li,Feng Geng,Jinbo Yue,Chao LiuPubMed 36609919
- Disease markers 2022:93129712022Inhibition of DEK Enhances Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoxue Tian,Zeyu Zhu,Guangming Wang,Jun Xu,Aibin Liang,Wenjun ZhangPubMed 35769815
- Frontiers in oncology 12:8724322022Construction and Verification of Immunohistochemistry Parameters-Based Classifier to Predict Local-Recurrence of Upper Tract Urothelial Carcinoma After Kidney-Sparing Surgery.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXu Cheng,Wentao Liu,Yijian Li,Yinhuai WangPubMed 35600373
- Journal of nanobiotechnology 20:1502022Triamcinolone acetonide-loaded nanoparticles encapsulated by CD90 MCSs-derived microvesicles drive anti-inflammatory properties and promote cartilage regeneration after osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuanlong Li,Qingqiang Tu,Dongmei Xie,Shurui Chen,Kai Gao,Xiaochun Xu,Ziji Zhang,Xifan MeiPubMed 35305656
- Experimental & molecular medicine 53:1356-13652021MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHua Jiang,Abu Moro,Jiaqi Wang,Dihua Meng,Xinli Zhan,Qingjun WeiPubMed 34531509
- Oxidative medicine and cellular longevity 2021:38431452021FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRongjin Luo,Shuai Li,Gaocai Li,Saideng Lu,Weifeng Zhang,Hui Liu,Jie Lei,Liang Ma,Wencan Ke,Zhiwei Liao,Bingjin Wang,Yu Song,Kun Wang,Yukun Zhang,Cao YangPubMed 34394825
- Frontiers in cell and developmental biology 9:6284632021Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHao Zhang,Chengling Zhao,Guojun Jiang,Bei Hu,Huifeng Zheng,Yimei Hong,Zhen Cui,Linli Shi,Xin Li,Fang Lin,Yue Ding,Lu Wei,Mimi Li,Xiaoting Liang,Yuelin ZhangPubMed 33738284
- Animal reproduction science 226:1067012021Senescent cells in rabbit, nutria and chinchilla testes-Results from histochemical and immunohistochemical studies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKrzysztof Lustofin et. al.PubMed 33516138
- Journal of clinical laboratory analysis 35:e236242020Upregulated microRNA-126 induces apoptosis of dental pulp stem cell via mediating PTEN-regulated Akt activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRucun Ge,Yongtao Lv,Peipei Li,Lin Xu,Xiaoya Feng,Hongshun QiPubMed 33150661
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ARPC5 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O15511
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Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
| Chicken | Predicted | Predicted |
| Cow | Predicted | Predicted |
| Pig | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Chicken, Cow, Pig | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Chicken, Cow, Pig | Dilution info - | Notes - |
Associated Products
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Target data
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Alternative names
ARC16, ARPC5, Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC
Recommended products
Rabbit Polyclonal ARPC5/p16 ARC antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 18 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARPC5 aa 1 to C-terminus.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ARPC5 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O15511
- Purification technique
Affinity purification Immunogen
- Specificity
This antibody is specific to the p16 ARC protein, database link: O15511. There is no observed cross reactivity to the CDKN2A/p16INK4a protein.
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ARPC5 also known as p16 ARC is a protein with a molecular weight of roughly 16 kilodaltons. It localizes largely in the cytoplasm and expresses in many cell types across species. The ARPC5 protein is a subunit of the Arp2/3 complex a vital component responsible for actin nucleation and branching during cytoskeleton remodeling. Researchers often examine ARPC5 through techniques such as western blot and immunohistochemistry using specific antibodies like anti-p16 or ARPC5 anticuerpo to identify its presence and distribution.
- Biological function summary
The ARPC5 protein is essential for effective actin polymerization making it an important contributor to cell motility and structure. As part of the Arp2/3 complex it interacts with other proteins to stimulate the growth of new actin filaments. This activity is important in processes like endocytosis phagocytosis and cell migration. Furthermore ARPC5 plays a role in maintaining cellular homeostasis and is involved in cellular signaling pathways.
- Pathways
Arpc5 influences the regulation of the actin cytoskeleton which intersects with pathways associated with cell movement and morphogenesis. It prominently relates to the WAVE complex working synergistically to regulate actin dynamics. ARPC5's involvement in the Rac1-WAVE-Arp2/3 pathway highlights its relationship with Rac1 a small GTPase known for regulating the cytoskeleton and cellular functions like adhesion and migration.
- Associated diseases and disorders
Imbalances in ARPC5 function can link to cancer progression and neurodegenerative diseases. Aberrant activity of the Arp2/3 complex which involves ARPC5 associates with increased cell invasion and metastasis in cancer. Additionally disruptions in ARPC5 activity connect to neurodegenerative conditions where cytoskeletal arrangement alterations play a role. The protein's interaction with others in the complex such as Rac1 further deepens its involvement in these diseases signaling potential targets for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-ARPC5/p16 ARC antibody (ab151303)
15% SDS PAGE
All lanes: Western blot - Anti-ARPC5/p16 ARC antibody (ab151303) at 1/500 dilution
Lane 1: THP1 whole cell lysate at 30 µg
Lane 2: HL60 whole cell lysate at 30 µg
Predicted band size: 16 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARPC5/p16 ARC antibody (ab151303)
Immunohistochemical analysis of paraffin-embedded Human colon cancer labeling p16 ARC with ab151303 antibody at 1/500 dilution.
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