Anti-ARPC5L antibody [EPR10274]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ARPC5L also known as Actin-Related Protein 2/3 Complex Subunit 5-Like is a smaller subunit of the ARP2/3 complex with a molecular mass around 16 kDa. This protein acts mechanically as an important regulator in the nucleation of new actin filaments aiding in the branching of the actin cytoskeleton. Scientists detect ARPC5L expression across diverse human tissues pointing to its broad role in cellular dynamics.

Biological function summary

ARPC5L aids actin filament dynamics as part of the ARP2/3 complex. This complex essential for cellular shape and motility helps drive the formation of lamellipodia and filopodian important structures in cell migration. Its function in remodeling the cytoskeleton makes it important in processes such as endocytosis and intracellular trafficking contributing to normal cell function and response to external stimuli.

Pathways

ARPC5L works within the cytoskeletal remodeling and cell motility pathways. Within the Wnt signaling pathway it plays a role in the regulation of cytoskeletal organization letting cells respond to signaling cues. The protein associates with others like ARPC1 and ARPC2 to facilitate these structural changes highlighting its importance to cellular adaptability and movement.

Associated diseases and disorders

ARPC5L has connections to cancers including breast and colorectal cancer. Abnormal regulation or mutation of the ARP2/3 complex can lead to altered cell migration and invasiveness contributing to cancer progression. The protein's interaction with elements of the Rho family such as RhoA and Rac1 integrates it into processes often hijacked in malignancies impacting how cells move invade and adhere.