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AB189437

Anti-Arrestin C antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal Arrestin C antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARR3 aa 300-400.

View Alternative Names

ARRX, CAR, ARR3, Arrestin-C, Cone arrestin, Retinal cone arrestin-3, X-arrestin, C-arrestin, cArr

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Arrestin C antibody - C-terminal (AB189437)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Arrestin C antibody - C-terminal (AB189437)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human eye, retina tissue labeling Arrestin C with ab189437 at 20 μg/ml.

Western blot - Anti-Arrestin C antibody - C-terminal (AB189437)
  • WB

Supplier Data

Western blot - Anti-Arrestin C antibody - C-terminal (AB189437)

All lanes:

Western blot - Anti-Arrestin C antibody - C-terminal (ab189437) at 1/500 dilution

Lane 1:

LOVO cell extract

Lane 2:

LOVO cell extract with immunizing peptide

Predicted band size: 43 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ARR3 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

P36575

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Arrestin C also known as S-antigen or retinal arrestin is a protein with a mass of approximately 48 kDa. It functions as a regulatory protein involved in the desensitization of G protein-coupled receptors (GPCRs) by binding to phosphorylated receptors preventing further G protein signaling. Expression of Arrestin C occurs predominantly in the retina specifically in photoreceptor cells where it plays an important role in visual signal transduction.
Biological function summary

Arrestin C operates by binding to light-activated and phosphorylated rhodopsin a G protein-coupled receptor. This binding facilitates the termination of the photoresponse effectively turning off the signal initiated by light exposure. Arrestin C forms a complex with phosphorylated rhodopsin which is important for maintaining proper vision. This prevents overstimulation of the photoreceptors and allows for the adaptation to varying light intensities.

Pathways

Arrestin C is deeply embedded in the visual phototransduction cascade. This pathway involves interactions with proteins such as rhodopsin and G proteins which lead to the conversion of light signals into neural signals within the retina. Arrestin C also interacts with the GRK (G protein-coupled receptor kinase) family members which phosphorylate rhodopsin marking it for Arrestin C binding and eventual inactivation.

Mutations or malfunctions in Arrestin C can result in progressive retinal disorders such as retinitis pigmentosa. This degenerative eye disease leads to the loss of rod photoreceptors and can eventually impair cone cells as well disrupting vision. Additionally disruptions in Arrestin C functionality are associated with congenital stationary night blindness due to improper inactivation of rhodopsin. Consequently understanding the interactions of Arrestin C with rhodopsin and other proteins remains important for therapeutic approaches targeting these ocular conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.
See full target information ARR3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 14:e70958 PubMed40567110

2025

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS-Dependent PTEN/AKT1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Chunlin Jiang,Chong Wang,Jian Ao,Yangping Liu,Fengjie Sun,Wangpan Shi,Zeyi Guo,Yanping Wu,Luxiang Gan,Meimei Wu,Yaofeng Zhi,Zijie Meng,Wanting Wu,Juanhua Wu,Yong Ye,Xin Zhang,Dong Ren,Mingxin Pan
View all publications
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Product promise

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