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AB88392

Anti-ARS2 antibody

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(1 Publication)

Mouse Polyclonal ARS2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

ARS2, ASR2, SRRT, Serrate RNA effector molecule homolog, Arsenite-resistance protein 2

3 Images
Western blot - Anti-ARS2 antibody (AB88392)
  • WB

Unknown

Western blot - Anti-ARS2 antibody (AB88392)

All lanes:

Western blot - Anti-ARS2 antibody (ab88392) at 1 µg/mL

All lanes:

human pancreas tissue lysate at 50 µg

Predicted band size: 101 kDa

Observed band size: 99 kDa

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Western blot - Anti-ARS2 antibody (AB88392)
  • WB

Unknown

Western blot - Anti-ARS2 antibody (AB88392)

All lanes:

Western blot - Anti-ARS2 antibody (ab88392) at 1 µg/mL

Lane 1:

ARS2 transfected 293T cell lysate at 50 µg

Lane 2:

Non transfected 293T cell lysate at 50 µg

Predicted band size: 101 kDa

Observed band size: 101 kDa

false

Western blot - Anti-ARS2 antibody (AB88392)
  • WB

Unknown

Western blot - Anti-ARS2 antibody (AB88392)

All lanes:

Western blot - Anti-ARS2 antibody (ab88392) at 1 µg/mL

All lanes:

Jurkat cell lysate at 50 µg

Predicted band size: 101 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARS2 also known as SRRT (serrate RNA effector molecule homolog) is a human protein encoded by the SRRT gene. ARS2 is a nuclear protein with an approximate molecular weight of 96 kDa. It is highly expressed in tissues such as the brain lung and liver. Inside the nucleus ARS2 interacts with various RNA-processing complexes binding to nascent RNA transcripts. The primary role of ARS2 centers around RNA metabolism where it manages and organizes the maturation of small RNAs.
Biological function summary

This protein assists in the capping processing and export of several RNA types including pre-miRNAs and other short-length RNAs. ARS2 forms part of a larger protein complex interacting with the Cap Binding Complex (CBC) and Integrator complex which helps regulate RNA stability and processing. Through these interactions ARS2 facilitates the proper maturation and quality control of RNA which is essential for maintaining cellular function and gene expression regulation.

Pathways

The activity of this protein notably aligns with the mRNA processing pathway and RNA surveillance pathway. Within these pathways ARS2 plays a role by participating in the post-transcriptional regulation that is interlinked with proteins like CBC and the nuclear RNA exosome complex. These collaborations enable tight control over RNA homeostasis ensuring that cells can adapt and respond to various cellular signals and stressors by modifying gene expression profiles.

Abnormalities in ARS2 function associate with neural development issues and cancer. In the context of neural development improper ARS2 activity affects RNA processing linking it to neurodevelopmental disorders where the faulty RNA regulation disrupts normal neural gene expression. Its role in cancer relates to unwanted proliferation stemming from misregulated RNA and altered gene expression patterns. Proteins connected to these diseases through ARS2 include DGCR8 (DiGeorge syndrome critical region gene 8) in neurodevelopment and Drosha in various cancers for their shared importance in RNA processing pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
See full target information SRRT
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Human reproduction open 2025:hoaf051 PubMed40919059

2025

Evaluating endometrial response to human chorionic gonadotropin: alterations in epigenetic regulation and extracellular vesicle cargo of endometrial stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Deimantė Žukauskaitė,Erika Girniūtė,Rūta Navakauskienė
View all publications
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Product promise

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