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AB85727

Anti-ARSB antibody

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(1 Publication)

Goat Polyclonal ARSB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARSB.

View Alternative Names

Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (AB85727)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (AB85727)

ab85727, at 5 μg/ml, staining ARSB in skeletal muscle tissue by Immunohistochemistry.

Western blot - Anti-ARSB antibody (AB85727)
  • WB

Unknown

Western blot - Anti-ARSB antibody (AB85727)

All lanes:

Western blot - Anti-ARSB antibody (ab85727) at 0.03 µg/mL

All lanes:

human heart lysate at 35 µg

Predicted band size: 60 kDa

Observed band size: 35 kDa,40 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ARSB. The exact immunogen used to generate this antibody is proprietary information.

P15848

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.03-0.1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ARSB protein also known as arylsulfatase B or N-acetylgalactosamine-4-sulfatase is an enzyme weighing approximately 62 kDa. It plays a role in breaking down glycosaminoglycans in the lysosomes. ARSB is highly expressed in tissues such as the liver kidney and skin where its enzymatic activity is important for normal cellular metabolism.
Biological function summary

ARSB functions in the degradation of dermatan sulfate and chondroitin sulfate types of glycosaminoglycans. It works as a monomer and is not part of a larger protein complex. This enzyme targets specific sulfated molecules facilitating their breakdown and recycling within the lysosomes.

Pathways

ARSB is actively involved in the lysosomal degradation pathway one of the key cellular processes for waste removal and recycling of macromolecules. This pathway includes collaboration with other lysosomal enzymes such as iduronate-2-sulfatase to complete the breakdown of complex molecules. ARSB's function in coordination with these enzymes supports cellular maintenance and metabolic balance.

ARSB malfunction is directly linked to the lysosomal storage disorder Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) characterized by the accumulation of glycosaminoglycans. This deficiency can lead to several symptoms including skeletal abnormalities and organomegaly. ARSB has also shown relevance in some inflammatory disorders where alterations in glycosaminoglycan breakdown impact cellular communication and tissue homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed : 19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed : 19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
See full target information ARSB
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Osteoarthritis and cartilage 22:986-95 PubMed24857976

2014

Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease.

Applications

Unspecified application

Species

Unspecified reactive species

M Luo,J Chen,S Li,H Sun,Z Zhang,Q Fu,J Li,J Wang,C E Hughes,B Caterson,J Cao
View all publications
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Product promise

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