Goat Polyclonal ARSB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARSB.
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Publications
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- Osteoarthritis and cartilage 22:986-952014Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesM Luo,J Chen,S Li,H Sun,Z Zhang,Q Fu,J Li,J Wang,C E Hughes,B Caterson,J CaoPubMed 24857976
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ARSB. The exact immunogen used to generate this antibody is proprietary information. Database link P15848
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.03000-0.10000 µg/mL | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
Alternative names
Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB
Recommended products
Goat Polyclonal ARSB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARSB.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ARSB. The exact immunogen used to generate this antibody is proprietary information. Database link P15848
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The ARSB protein also known as arylsulfatase B or N-acetylgalactosamine-4-sulfatase is an enzyme weighing approximately 62 kDa. It plays a role in breaking down glycosaminoglycans in the lysosomes. ARSB is highly expressed in tissues such as the liver kidney and skin where its enzymatic activity is important for normal cellular metabolism.
- Biological function summary
ARSB functions in the degradation of dermatan sulfate and chondroitin sulfate types of glycosaminoglycans. It works as a monomer and is not part of a larger protein complex. This enzyme targets specific sulfated molecules facilitating their breakdown and recycling within the lysosomes.
- Pathways
ARSB is actively involved in the lysosomal degradation pathway one of the key cellular processes for waste removal and recycling of macromolecules. This pathway includes collaboration with other lysosomal enzymes such as iduronate-2-sulfatase to complete the breakdown of complex molecules. ARSB's function in coordination with these enzymes supports cellular maintenance and metabolic balance.
- Associated diseases and disorders
ARSB malfunction is directly linked to the lysosomal storage disorder Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) characterized by the accumulation of glycosaminoglycans. This deficiency can lead to several symptoms including skeletal abnormalities and organomegaly. ARSB has also shown relevance in some inflammatory disorders where alterations in glycosaminoglycan breakdown impact cellular communication and tissue homeostasis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (ab85727)
ab85727, at 5 μg/ml, staining ARSB in skeletal muscle tissue by Immunohistochemistry.
Western blot - Anti-ARSB antibody (ab85727)
All lanes: Western blot - Anti-ARSB antibody (ab85727) at 0.03 µg/mL
All lanes: human heart lysate at 35 µg
Predicted band size: 60 kDa
Observed band size: 35 kDa, 40 kDa
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