AB172633

Anti-ARVCF antibody [EPR10036(2)]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal ARVCF antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Splicing regulator ARVCF, Armadillo repeat protein deleted in velo-cardio-facial syndrome, ARVCF

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-ARVCF antibody [EPR10036(2)] (AB172633)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ARVCF antibody [EPR10036(2)] (AB172633)

Immunocytochemistry/ Immunofluorescence analysis of HeLa cells labeling ARVCF with ab172633 at a 1/50 dilution. DAPI nuclear staining (blue).

Supplier Data

Western blot - Anti-ARVCF antibody [EPR10036(2)] (AB172633)

All lanes:

Western blot - Anti-ARVCF antibody [EPR10036(2)] (ab172633) at 1/1000 dilution

Lane 1:

293T lysate at 10 µg

Lane 2:

HeLa lysate at 10 µg

Lane 3:

HepG2 lysate at 10 µg

Lane 4:

A431 lysate at 10 µg

Predicted band size: 105 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10036(2)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARVCF also known as Armadillo Repeat gene deleted in Velo-Cardio-Facial Syndrome encodes a protein involved in cell adhesion and signaling. This protein weighs around 86 kDa and contains armadillo repeat domains facilitating interactions with other membrane-associated proteins. ARVCF is expressed in various tissues including the heart and brain suggesting its versatile role in cellular functioning. Localization in adherens junctions indicates its importance in maintaining structural integrity.

Biological function summary

The function of ARVCF supports cell adhesion and communication. It participates in complex formation with catenins and cadherins which are critical for adherens junctions. These complexes enable the anchoring of cytoskeletal elements to the cell membrane aiding in stable cell-cell contact. ARVCF modulates the transduction of signals that regulate cellular behaviors such as migration and proliferation through these interactions.

Pathways

ARVCF plays a role in Wnt signaling and adherens junction pathways. The protein interacts with β-catenin a significant player in Wnt pathway influencing gene expression related to cell growth and differentiation. ARVCF also associates with proteins involved in the assembly and maintenance of adherens junctions further emphasizing its connection to cellular architecture and signaling.

ARVCF has been linked to velo-cardio-facial syndrome and some forms of cancer. These associations suggest a connection between ARVCF dysfunction and disruptions in normal cell signaling and adhesion processes. In cancer altered ARVCF expression can impact the interaction with β-catenin and other junction-related proteins potentially influencing tumor progression and metastasis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Contributes to the regulation of alternative splicing of pre-mRNAs.

See full target information ARVCF

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cells 14: PubMed40558556

2025

A Novel Modulator of Resistance for Oxaliplatin-Based Therapy for Colorectal Cancer: The ESCRT Family Member VPS4A.

Applications

Unspecified application

Species

Unspecified reactive species

Noha M Abdelrazik,Anjana Patel,Andrew Conn,Christopher W Sutton,Sriharsha Kantamneni,Steven D Shnyder

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ARVCF antibody [EPR10036(2)]

Immunocytochemistry/ Immunofluorescence - Anti-ARVCF antibody [EPR10036(2)] (AB172633)

Western blot - Anti-ARVCF antibody [EPR10036(2)] (AB172633)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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Product promise