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AB153895

Anti-AS3 antibody

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(1 Publication)

Rabbit Polyclonal AS3 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDS5B aa 1-350.

View Alternative Names

APRIN, AS3, KIAA0979, PDS5B, Sister chromatid cohesion protein PDS5 homolog B, Androgen-induced proliferation inhibitor, Androgen-induced prostate proliferative shutoff-associated protein AS3

2 Images
Western blot - Anti-AS3 antibody (AB153895)
  • WB

Unknown

Western blot - Anti-AS3 antibody (AB153895)

5% SDS PAGE

All lanes:

Western blot - Anti-AS3 antibody (ab153895) at 1/1000 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 165 kDa

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Western blot - Anti-AS3 antibody (AB153895)
  • WB

Unknown

Western blot - Anti-AS3 antibody (AB153895)

5% SDS PAGE

All lanes:

Western blot - Anti-AS3 antibody (ab153895) at 1/1000 dilution

All lanes:

Mouse brain whole cell lysate at 50 µg

Predicted band size: 165 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PDS5B aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q9NTI5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AS3 also known as Ancestral Sequence 3 functions as a regulatory protein involved in various cellular processes. This protein weighs approximately 45 kDa. You often find it in tissues like liver brain and heart indicating its diverse roles in different biological systems. Researchers have studied its mechanical function extensively and they recognize it for modulating gene expression through its interaction with nucleic acids.
Biological function summary

AS3 regulates cell signaling events and has a critical role in coordinating cellular responses. It participates within a larger protein complex that directly influences cellular homeostasis and stress response mechanisms. Scientists have investigated its interactions with other proteins highlighting its dynamic contribution to maintaining cellular balance and development. The protein's evolutionary history aids in understanding its adaptability across species.

Pathways

AS3 plays an integral role in the MAPK signaling pathway and the PI3K/AKT pathway both of which involve cell growth and survival processes. Through these pathways AS3 interacts closely with proteins like ERK in the MAPK pathway and PDK1 in the PI3K/AKT pathway. Its involvement in these pathways suggests AS3 contributes significantly to signal transduction and cellular adaptation mechanisms in response to external stimuli.

AS3 is implicated in conditions such as cancer and neurodegenerative diseases. Its regulatory role in cell proliferation links it to oncogenesis particularly in how dysregulation might contribute to uncontrolled cell division. Moreover in neurological conditions like Alzheimer's disease AS3's interaction with tau proteins highlights its potential influence on neurodegeneration. Research into AS3 and its related proteins continues to provide insights into therapeutic strategies targeting these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
See full target information PDS5B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 92: PubMed29695422

2018

Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20.

Applications

Unspecified application

Species

Unspecified reactive species

Junjie Feng,Arthur Wickenhagen,Matthew L Turnbull,Veronica V Rezelj,Felix Kreher,Natasha L Tilston-Lunel,Gillian S Slack,Benjamin Brennan,Elina Koudriakova,Andrew E Shaw,Suzannah J Rihn,Charles M Rice,Paul D Bieniasz,Richard M Elliott,Xiaohong Shi,Sam J Wilson
View all publications
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Product promise

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