Rabbit Polyclonal AS3 antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PDS5B aa 1-350.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PDS5B aa 1-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NTI5
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Predicted |
| Chicken | Predicted |
| Xenopus tropicalis | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Chicken, Xenopus tropicalis | Dilution info - | Notes - |
Target data
Function
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
Alternative names
APRIN, AS3, KIAA0979, PDS5B, Sister chromatid cohesion protein PDS5 homolog B, Androgen-induced proliferation inhibitor, Androgen-induced prostate proliferative shutoff-associated protein AS3
Recommended products
Rabbit Polyclonal AS3 antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PDS5B aa 1-350.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PDS5B aa 1-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NTI5
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
AS3 also known as Ancestral Sequence 3 functions as a regulatory protein involved in various cellular processes. This protein weighs approximately 45 kDa. You often find it in tissues like liver brain and heart indicating its diverse roles in different biological systems. Researchers have studied its mechanical function extensively and they recognize it for modulating gene expression through its interaction with nucleic acids.
- Biological function summary
AS3 regulates cell signaling events and has a critical role in coordinating cellular responses. It participates within a larger protein complex that directly influences cellular homeostasis and stress response mechanisms. Scientists have investigated its interactions with other proteins highlighting its dynamic contribution to maintaining cellular balance and development. The protein's evolutionary history aids in understanding its adaptability across species.
- Pathways
AS3 plays an integral role in the MAPK signaling pathway and the PI3K/AKT pathway both of which involve cell growth and survival processes. Through these pathways AS3 interacts closely with proteins like ERK in the MAPK pathway and PDK1 in the PI3K/AKT pathway. Its involvement in these pathways suggests AS3 contributes significantly to signal transduction and cellular adaptation mechanisms in response to external stimuli.
- Associated diseases and disorders
AS3 is implicated in conditions such as cancer and neurodegenerative diseases. Its regulatory role in cell proliferation links it to oncogenesis particularly in how dysregulation might contribute to uncontrolled cell division. Moreover in neurological conditions like Alzheimer's disease AS3's interaction with tau proteins highlights its potential influence on neurodegeneration. Research into AS3 and its related proteins continues to provide insights into therapeutic strategies targeting these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-AS3 antibody (ab153895)
5% SDS PAGE
All lanes: Western blot - Anti-AS3 antibody (ab153895) at 1/1000 dilution
All lanes: Mouse brain whole cell lysate at 50 µg
Predicted band size: 165 kDa
Western blot - Anti-AS3 antibody (ab153895)
5% SDS PAGE
All lanes: Western blot - Anti-AS3 antibody (ab153895) at 1/1000 dilution
All lanes: Raji whole cell lysate at 30 µg
Predicted band size: 165 kDa
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