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AB157102

Anti-ASCC1 antibody

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(1 Publication)

Rabbit Polyclonal ASCC1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ASCC1 aa 1-50.

View Alternative Names

CGI-18, ASCC1, Activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit p50, Trip4 complex subunit p50

1 Images
Western blot - Anti-ASCC1 antibody (AB157102)
  • WB

Unknown

Western blot - Anti-ASCC1 antibody (AB157102)

All lanes:

Western blot - Anti-ASCC1 antibody (ab157102) at 0.4 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

293T whole cell lysate at 50 µg

Lane 4:

Jurkat whole cell lysate at 50 µg

Predicted band size: 45 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ASCC1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q8N9N2

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab157102 was affinity purified using an epitope specific to ASCC1 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ASCC1 also known as Activating Signal Cointegrator 1 Complex Subunit 1 serves as a part of an important protein complex involved in transcriptional regulation. This protein weighs approximately 86 kilodaltons and exhibits expression in various tissues including the heart and skeletal muscles. ASCC1 acts mechanically by contributing to the remodeling of chromatin assisting in the process of transcriptional activation by modifying how genes are accessed within the chromatin structure.
Biological function summary

ASCC1 plays an important role in the functioning of the ASC-1 complex which includes other associated subunits such as ASCC2 and ASCC3. This complex is involved in the regulation of gene expression by influencing the transcriptional machinery. Through interaction with transcriptional coactivators ASCC1 modulates the transcription of specific genes aiding in cellular response mechanisms.

Pathways

Researchers have identified ASCC1 as pivotal in the DNA repair process and the transcription-coupled nucleotide excision repair pathway. Within the DNA repair pathway ASCC1 collaborates with proteins such as XPC in addressing DNA damage and maintaining genomic stability. This integration into critical pathways illustrates its influence on cellular processes that protect the genomic integrity from various types of damage.

Scientists link mutations in ASCC1 to esophageal cancer and spinal muscular atrophy. In esophageal cancer altered ASCC1 expression influences tumorigenic pathways often in conjunction with proteins such as p53. Similarly dysfunction in spinal muscular atrophy involves protein partners where ASCC1 abnormalities disrupt normal cellular mechanisms resulting in the disease's characteristic symptoms. Understanding these connections offers potential insights into therapeutic approaches targeting ASCC1-related pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in DNA damage repair as component of the ASCC complex (PubMed : 29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed : 12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
See full target information ASCC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell 188:5384-5402.e25 PubMed40701149

2025

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress.

Applications

Unspecified application

Species

Unspecified reactive species

Erica Wolin,Jimmy K Guo,Mario R Blanco,Isabel N Goronzy,Darvesh Gorhe,Wenzhao Dong,Andrew A Perez,Abdurrahman Keskin,Elizabeth Valenzuela,Ahmed A Abdou,Carl R Urbinati,Ross Kaufhold,H Tomas Rube,Jailson Brito Querido,Mitchell Guttman,Marko Jovanovic
View all publications
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