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AB190638

Anti-ASIC3 antibody

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(5 Publications)

Rabbit Polyclonal ASIC3 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ASIC3 aa 150-250.

View Alternative Names

ACCN3, SLNAC1, TNAC1, ASIC3, Acid-sensing ion channel 3, hASIC3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hTNaC1

1 Images
Western blot - Anti-ASIC3 antibody (AB190638)
  • WB

Supplier Data

Western blot - Anti-ASIC3 antibody (AB190638)

All lanes:

Western blot - Anti-ASIC3 antibody (ab190638) at 1/500 dilution

All lanes:

HepG2 cell lysate

Predicted band size: 58 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ASIC3 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q9UHC3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ASIC3 also known as Acid-Sensing Ion Channel 3 or DRASIC is a protein channel involved in detecting variations in pH. This protein has a molecular mass of approximately 56 kDa and falls within the ASIC family of proton-gated sodium channels. ASIC3 is widely expressed in peripheral sensory neurons particularly in dorsal root and trigeminal ganglia which are areas pivotal for detecting pain and mechanosensation. The localization suggests a specialized role in responding to acidic environments.
Biological function summary

ASIC3 functions through responding to changes in extracellular pH allowing sodium ions to enter cells when the pH decreases. It does not act solo and usually forms homomeric or heteromeric complexes with other ASIC subunits such as ASIC1 or ASIC2. This combination enhances its sensitivity and response diversity to varying acidic conditions contributing to processes like pain sensing and mechanotransduction. In muscle tissue ASIC3 plays a role in sensing metabolic changes that occur during intensive exercise.

Pathways

ASIC3 integrates into systems related to pain and mechanosensory pathways. It participates prominently in the nociceptive signaling pathway associated with the perception of pain induced by protons. ASIC3 works alongside proteins such as TRPV1 another ion channel known for its role in pain and thermal sensation. Interconnected with these pathways ASIC3 impacts physiological responses like hyperalgesia in acidic environments.

ASIC3 significantly contributes to conditions such as chronic pain and acid-induced pain from tissue injury or inflammation. It associates with migraines and inflammatory pain magnifying pain sensations under acidic conditions. In these contexts ASIC3 collaborates with proteins like the NaV1.7 sodium channel further influencing nerve excitability and pain perception. Targeting ASIC3 could potentially alleviate symptoms associated with these pain disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
See full target information ASIC3
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

NPJ precision oncology 8:274 PubMed39587279

2024

Deep mutual learning on hybrid amino acid PET predicts H3K27M mutations in midline gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Yifan Yuan,Guanglei Li,Shuhao Mei,Mingtao Hu,Ying-Hua Chu,Yi-Cheng Hsu,Chaolin Li,Jianping Song,Jie Hu,Danyang Feng,Fang Xie,Yihui Guan,Qi Yue,Mianxin Liu,Ying Mao

Scientific reports 14:20421 PubMed39227705

2024

Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Balboni,Camilla D'Angelo,Nicoletta Collura,Simone Brusco,Claudia Di Berardino,Altea Targa,Beatrice Massoti,Eloise Mastrangelo,Mario Milani,Pierfausto Seneci,Vania Broccoli,Luca Muzio,Rossella Galli,Andrea Menegon

Military Medical Research 11:17 PubMed38475827

2024

Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking.

Applications

Unspecified application

Species

Unspecified reactive species

Man-Xiu Xie,Ren-Chun Lai,Yi-Bin Xiao,Xi Zhang,Xian-Ying Cao,Xiao-Yu Tian,An-Nan Chen,Zi-Yi Chen,Yan Cao,Xiao Li,Xiao-Long Zhang

Journal of neuroinflammation 18:96 PubMed33874962

2021

Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Wei,Lina Wang,Jie Hua,Xiao-Hong Jin,Fuhai Ji,Ke Peng,Bin Zhou,Jianping Yang,Xiao-Wen Meng

Experimental physiology 105:809-818 PubMed32105387

2020

Metabo- and mechanoreceptor expression in human heart failure: Relationships with the locomotor muscle afferent influence on exercise responses.

Applications

Unspecified application

Species

Unspecified reactive species

Joshua R Smith,Corey R Hart,Paola A Ramos,Joshua G Akinsanya,Ian R Lanza,Michael J Joyner,Timothy B Curry,Thomas P Olson
View all publications
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