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AB155286

Anti-Aspartyl Aminopeptidase antibody [EPR10300]

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(1 Publication)

Rabbit Recombinant Monoclonal Aspartyl Aminopeptidase antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

ASPEP, DAP, DNPEP, Aspartyl aminopeptidase

1 Images
Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10300] (AB155286)
  • WB

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Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10300] (AB155286)

All lanes:

Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10300] (ab155286) at 1/1000 dilution

Lane 1:

MCF7 cell lysate at 10 µg

Lane 2:

Human fetal lung lysate at 10 µg

Lane 3:

U-87 MG cell lysate at 10 µg

Lane 4:

HepG2 cell lysate at 10 µg

Lane 5:

Human fetal kidney lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 52 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10300

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aspartyl Aminopeptidase also known as DNPEP is a metallopeptidase enzyme that mechanically cleaves N-terminal aspartic acid residues from peptides. This enzyme has a molecular mass of about 52 kDa. Aspartyl Aminopeptidase is expressed in various tissues with high abundance in liver and kidney. Its subcellular location is mainly the cytosol where it is involved in protein processing and turnover.
Biological function summary

Aspastyl aminopeptidase plays a role in peptide metabolism by trimming aspartic acid residues aiding in protein degradation and maturation. It functions independently and is not known to be part of a larger protein complex. Its activity facilitates the maintenance of normal peptide levels which is essential for various cellular processes.

Pathways

Aspartyl aminopeptidase is involved in the renin-angiotensin system an important regulator of blood pressure and fluid balance. Within this pathway it modulates levels of angiotensin peptides. It also interacts with other proteins such as angiotensin-converting enzyme (ACE) and neprilysin highlighting its importance in cardiovascular homeostasis.

Research links aspartyl aminopeptidase to essential hypertension due to its role in the renin-angiotensin system. Abnormal activity of this enzyme might contribute to alterations in angiotensin metabolism therefore impacting blood pressure regulation. Additionally dysregulation may have implications in kidney diseases where interaction with ACE affects renal function and blood pressure control.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.
See full target information DNPEP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biochemistry and biophysics reports 29:101223 PubMed35146136

2022

Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Yasunori Fukumoto,Kemmu Matsuhashi,Yu-Ki Tanaka,Noriyuki Suzuki,Yasumitsu Ogra
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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