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AB154522

Anti-ASTN1 antibody

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(2 Publications)

Rabbit Polyclonal ASTN1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ASTN1 aa 300-600.

View Alternative Names

ASTN, KIAA0289, ASTN1, Astrotactin-1

1 Images
Western blot - Anti-ASTN1 antibody (AB154522)
  • WB

Unknown

Western blot - Anti-ASTN1 antibody (AB154522)

5% SDS PAGE

All lanes:

Western blot - Anti-ASTN1 antibody (ab154522) at 1/1000 dilution

All lanes:

mouse brain lysate at 50 µg

Predicted band size: 145 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ASTN1 aa 300-600. The exact immunogen used to generate this antibody is proprietary information.

O14525

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Astrotactin 1 (ASTN1) is a protein that plays a mechanical role in cell adhesion and migration. This protein with an approximate mass of 160 kDa facilitates interactions between neuronal cells. Researchers have commonly referred to ASTN1 in alternative names including "Astrotactin." It is expressed in the central nervous system with significant expression in developing neurons.
Biological function summary

ASTN1 supports the movement and proper positioning of neurons particularly during the developmental stages of the brain. As part of a protein complex ASTN1 functions in neuronal migration processes essential for the formation of organized brain structures. It contributes to the cellular interactions with various extracellular matrix components aiding in the precise layering of neurons.

Pathways

Several neurological pathways involve ASTN1's activity in guiding neurons to their final destinations. It plays a role in the Reelin signaling pathway where it interacts with proteins like Dab1 and Reelin to orchestrate neuronal positioning. Additionally the protein contributes to regulating cellular interactions that are critical for synaptic differentiation and organization.

ASTN1 has associations with neurological conditions such as lissencephaly and autism spectrum disorder. Lissencephaly a condition linked to improper neuronal migration highlights the vital function of ASTN1 in brain development. Researchers have also found connections between ASTN1 and the Reelin protein both implicated in neurodevelopmental disorders suggesting potential pathways for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.
See full target information ASTN1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Bioengineered 13:11933-11944 PubMed35549815

2022

Bone mesenchymal stem cells (BMSCs)-derived exosomal microRNA-21-5p regulates Kruppel-like factor 3 (KLF3) to promote osteoblast proliferation .

Applications

Unspecified application

Species

Unspecified reactive species

Murong You,Zisheng Ai,Jihuan Zeng,Yang Fu,Liang Zhang,Xin Wu

Oncology reports 44:1425-1440 PubMed32945491

2020

ASTN1 is associated with immune infiltrates in hepatocellular carcinoma, and inhibits the migratory and invasive capacity of liver cancer via the Wnt/β‑catenin signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qi-Feng Chen,Feng Shi,Tao Huang,Chaoyun Huang,Lujun Shen,Peihong Wu,Wang Li
View all publications
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