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AB67992

Anti-ATAD3A antibody

5

(1 Review)

|

(1 Publication)

Mouse Polyclonal ATAD3A antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ATAD3A.

View Alternative Names

ATPase family AAA domain-containing protein 3A, ATAD3A

2 Images
Western blot - Anti-ATAD3A antibody (AB67992)
  • WB

Unknown

Western blot - Anti-ATAD3A antibody (AB67992)

All lanes:

Western blot - Anti-ATAD3A antibody (ab67992) at 1/500 dilution

All lanes:

Human spleen tissue lysate at 25 µg

Secondary

All lanes:

Goat anti-mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

Predicted band size: 71 kDa

Observed band size: 71 kDa

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Western blot - Anti-ATAD3A antibody (AB67992)
  • WB

Unknown

Western blot - Anti-ATAD3A antibody (AB67992)

All lanes:

Western blot - Anti-ATAD3A antibody (ab67992) at 1/500 dilution

Lane 1:

ATAD3A transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 71 kDa

Observed band size: 71 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ATAD3A.

Q9NVI7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATAD3A also known as ATPase family AAA domain-containing protein 3A functions as a mitochondrial membrane protein with an approximate molecular mass of 67 kDa. This protein is expressed widely in human tissues with high levels detected in the brain heart and liver. Mechanically ATAD3A facilitates interactions between the inner and outer mitochondrial membranes playing a role in mitochondrial dynamics and integrity.
Biological function summary

The maintenance of mitochondrial structure and function heavily involves ATAD3A. It forms part of a multiprotein complex that ensures the proper organization of mitochondrial nucleoids thereby regulating mitochondrial DNA replication and transcription. It also participates in maintaining the stability and distribution of mitochondrial proteins contributing to the overall energy metabolism of the cell.

Pathways

ATAD3A engages in key processes related to mitochondrial biogenesis and dynamics. Involvement in pathways like the mitochondrial DNA replication pathway and the energy production pathway highlights its role in maintaining cellular homeostasis. The protein interacts with others including DRP1 and MFN2 essential proteins that regulate mitochondrial fission and fusion processes contributing to its role in energy metabolism.

ATAD3A has associations with several conditions affecting mitochondrial function. Mutations or dysregulation in ATAD3A contribute to neurodegenerative disorders and certain types of cancer. It has been linked to Parkinson's disease due to its influence on mitochondrial homeostasis and is connected with Alzheimer's disease through its interactions with proteins like PINK1 another critical player in mitochondrial maintenance and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed : 17210950, PubMed : 20154147, PubMed : 22453275, PubMed : 31522117, PubMed : 37832546, PubMed : 39116259). May play an important role in mitochondrial protein synthesis (PubMed : 22453275). May also participate in mitochondrial DNA replication (PubMed : 17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed : 17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed : 22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed : 31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response : specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed : 39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed : 39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed : 37832546).
See full target information ATAD3A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 8:109924-109940 PubMed29299119

2017

Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches.

Applications

Unspecified application

Species

Unspecified reactive species

Ségolène Hescot,Larbi Amazit,Marie Lhomme,Simon Travers,Anais DuBow,Stephanie Battini,Geoffrey Boulate,Izzie Jacques Namer,Anne Lombes,Anatol Kontush,Alessio Imperiale,Eric Baudin,Marc Lombes
View all publications
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