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AB18123

Anti-ATF1 - S.pombe antibody [ATF1 2A9/8]

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(8 Publications)

Mouse Monoclonal ATF1 - S.pombe antibody. Suitable for IP, WB and reacts with Schizosaccharomyces pombe samples. Cited in 8 publications.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ATF1 2A9/8

Isotype

IgG2a

Carrier free

No

Reacts with

Schizosaccharomyces pombe

Applications

IP, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Schizosaccharomyces pombe": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Product details

ATF1 in S. pombe is a bZIP transcription factor with strong homology to the mammalian factor ATF1.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATF1 also known as Activating Transcription Factor 1 is a transcription factor in Schizosaccharomyces pombe (S. pombe). ATF1 has a mass of approximately 45 kDa and is expressed in the nucleus. It works as a DNA-binding protein that regulates gene expression by binding to cAMP response elements. ATF1's activity depends on phosphorylation which modulates its function during cellular stress responses.
Biological function summary

ATF1 in S. pombe plays an essential role in stress responses and cell cycle regulation. It acts not as an isolated unit but as part of a transcriptional activation complex with Pcr1. This complex formation allows ATF1 to regulate various genes involved in responses to oxidative stress and osmotic stress ensuring cell survival under adverse conditions. Its activation can lead to the expression of genes needed for cell adaptation and maintenance.

Pathways

ATF1 is heavily involved in the stress-activated protein kinase (SAPK) signaling pathway. In this pathway ATF1 interacts with proteins such as Sty1 which phosphorylates ATF1 promoting its activity. This interaction is an important link in the cascade that enables cellular adaptation to environmental changes. The SAPK pathway illustrates ATF1’s involvement in regulating gene expression responses that ensure proper cellular reaction to stress stimuli.

ATF1's regulation in S. pombe serves as a model for understanding stress response mechanisms relevant in human diseases like cancer. Dysregulation of pathways involving ATF1 can relate to abnormal cellular stress responses and apoptosis potentially leading to carcinogenesis. Other proteins like Sty1 also share connections through these dysregulated pathways and contribute to disease states reflecting their potential roles in stress-induced cellular malfunctions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ATF1 - S.pombe
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113298 PubMed40894867

2025

Control of stress-activated Cdc42 dynamics by the MAP kinase Sty1-NDR kinase Orb6 regulatory axis.

Applications

Unspecified application

Species

Unspecified reactive species

Laura P Doyle,Jun-Song Chen,Kathleen L Gould,Dannel McCollum,Fulvia Verde

eLife 13: PubMed38289024

2024

Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.

Applications

Unspecified application

Species

Unspecified reactive species

Li Sun,Libo Liu,Chunlin Song,Yamei Wang,Quan-Wen Jin

PloS one 19:e0294191 PubMed38252660

2024

Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.

Applications

Unspecified application

Species

Unspecified reactive species

Yusuke Tsuruta,Satoshi Senmatsu,Hana Oe,Charles S Hoffman,Kouji Hirota

Nucleic acids research 50:3727-3744 PubMed35348762

2022

Facultative heterochromatin formation in rDNA is essential for cell survival during nutritional starvation.

Applications

Unspecified application

Species

Unspecified reactive species

Hayato Hirai,Naomichi Takemata,Miki Tamura,Kunihiro Ohta

Nucleic acids research 49:9809-9820 PubMed34486060

2021

Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Wakana Koda,Satoshi Senmatsu,Takuya Abe,Charles S Hoffman,Kouji Hirota

eLife 9: PubMed32915139

2020

Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.

Applications

Unspecified application

Species

Unspecified reactive species

Elisa Gómez-Gil,Rebeca Martín-García,Jero Vicente-Soler,Alejandro Franco,Beatriz Vázquez-Marín,Francisco Prieto-Ruiz,Teresa Soto,Pilar Pérez,Marisa Madrid,Jose Cansado

mBio 11: PubMed31911490

2020

RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Francisco Prieto-Ruiz,Jero Vicente-Soler,Alejandro Franco,Elisa Gómez-Gil,Marta Sánchez-Marinas,Beatriz Vázquez-Marín,Rosa Aligué,Marisa Madrid,Sergio Moreno,Teresa Soto,José Cansado

Nucleic acids research 45:9361-9371 PubMed28934464

2017

Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Applications

Unspecified application

Species

Unspecified reactive species

Ryuta Asada,Miki Umeda,Akira Adachi,Satoshi Senmatsu,Takuya Abe,Hiroshi Iwasaki,Kunihiro Ohta,Charles S Hoffman,Kouji Hirota
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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