Anti-ATF1 - S.pombe antibody [ATF1 2A9/8]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ATF1 also known as Activating Transcription Factor 1 is a transcription factor in Schizosaccharomyces pombe (S. pombe). ATF1 has a mass of approximately 45 kDa and is expressed in the nucleus. It works as a DNA-binding protein that regulates gene expression by binding to cAMP response elements. ATF1's activity depends on phosphorylation which modulates its function during cellular stress responses.

Biological function summary

ATF1 in S. pombe plays an essential role in stress responses and cell cycle regulation. It acts not as an isolated unit but as part of a transcriptional activation complex with Pcr1. This complex formation allows ATF1 to regulate various genes involved in responses to oxidative stress and osmotic stress ensuring cell survival under adverse conditions. Its activation can lead to the expression of genes needed for cell adaptation and maintenance.

Pathways

ATF1 is heavily involved in the stress-activated protein kinase (SAPK) signaling pathway. In this pathway ATF1 interacts with proteins such as Sty1 which phosphorylates ATF1 promoting its activity. This interaction is an important link in the cascade that enables cellular adaptation to environmental changes. The SAPK pathway illustrates ATF1’s involvement in regulating gene expression responses that ensure proper cellular reaction to stress stimuli.

Associated diseases and disorders

ATF1's regulation in S. pombe serves as a model for understanding stress response mechanisms relevant in human diseases like cancer. Dysregulation of pathways involving ATF1 can relate to abnormal cellular stress responses and apoptosis potentially leading to carcinogenesis. Other proteins like Sty1 also share connections through these dysregulated pathways and contribute to disease states reflecting their potential roles in stress-induced cellular malfunctions.