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AB81596

Anti-ATG16L2 antibody

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(1 Publication)

Rabbit Polyclonal ATG16L2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATG16L2.

View Alternative Names

WDR80, ATG16L2, Protein Atg16l2, APG16-like 2, Autophagy-related protein 16-2, WD repeat-containing protein 80

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ATG16L2. The exact immunogen used to generate this antibody is proprietary information.

Q8NAA4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATG16L2 also known as Autophagy Related 16 Like 2 is a protein that plays a role in the autophagy process. It weighs approximately 80 kDa. Scientists find ATG16L2 in various tissues with notable expression in immune system-related tissues. The protein exhibits structural similarities to ATG16L1 another key autophagy protein and shares a role in the formation of autophagosomes by providing a scaffold for the recruitment of other autophagic proteins.
Biological function summary

ATG16L2 contributes to cellular homeostasis by supporting autophagic activity. It associates with the ATG5-ATG12 complex essential for the formation of autophagosomes. This interaction ensures the delivery of cytoplasmic content to lysosomes for degradation an important step in autophagic flux. The presence of ATG16L2 in immune cells suggests an additional role in modulating immune responses and maintaining balance during stress conditions.

Pathways

ATG16L2 is primarily involved in the autophagy and lysosomal degradation pathways. These pathways are important for maintaining cell survival under nutrient-deprived conditions. Within its pathways ATG16L2 interacts closely with proteins like LC3 which is necessary for autophagosome maturation and function. It's part of the larger network of proteins orchestrating the cellular response to metabolic stress and damage.

Alterations in ATG16L2 expression or function have been linked to certain autoimmune diseases such as Crohn's disease. This connection suggests a role in the modulation of immune function that might affect inflammation. ATG16L2 like its counterpart ATG16L1 shares a relationship with proteins involved in immune regulation highlighting its potential impact on immune-mediated disorders. Understanding the regulation of ATG16L2 could provide insights into therapeutic strategies for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.
See full target information ATG16L2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 6:e21156 PubMed21887213

2011

The D153del mutation in GNB3 gene causes tissue specific signalling patterns and an abnormal renal morphology in Rge chickens.

Applications

Unspecified application

Species

Unspecified reactive species

Hemanth Tummala,Stewart Fleming,Paul M Hocking,Daniel Wehner,Zahid Naseem,Manir Ali,Christopher F Inglehearn,Nikolai Zhelev,Douglas H Lester
View all publications
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Product promise

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