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AB191856

Anti-ATMIN antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal ATMIN antibody. N-terminal. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATMIN.

View Alternative Names

KIAA0431, ZNF822, ATMIN, ATM interactor, ATM/ATR-substrate CHK2-interacting zinc finger protein, Zinc finger protein 822, ASCIZ

3 Images
Immunocytochemistry - Anti-ATMIN antibody - N-terminal (AB191856)
  • ICC

Supplier Data

Immunocytochemistry - Anti-ATMIN antibody - N-terminal (AB191856)

Immunocytochemical analysis of A431 cells labeling ATMIN with ab191856 at 5 μg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-ATMIN antibody - N-terminal (AB191856)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ATMIN antibody - N-terminal (AB191856)

Immunofluorescent analysis of A431 cells labeling ATMIN with ab191856 at 2.5 μg/ml.

Western blot - Anti-ATMIN antibody - N-terminal (AB191856)
  • WB

Supplier Data

Western blot - Anti-ATMIN antibody - N-terminal (AB191856)

Lane 1:

Western blot - Anti-ATMIN antibody - N-terminal (ab191856) at 1 µg/mL

Lane 2:

Western blot - Anti-ATMIN antibody - N-terminal (ab191856) at 2 µg/mL

All lanes:

293 cell lysate at 15 µg

Predicted band size: 88 kDa

Observed band size: 72 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, ICC, WB

applications

Immunogen

Synthetic Peptide within Human ATMIN. The exact immunogen used to generate this antibody is proprietary information.

O43313

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "5 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "2.5 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATMIN also referred to as ASCIZ (ATM Substrate Chk2-Interacting Zn2+-finger protein) is a protein of approximately 96 kDa. It functions mechanically as a transcription factor regulating the expression of various genes. ATMIN is expressed in multiple tissues but shows high expression in the brain and testes. It plays a role in maintaining cellular homeostasis through its regulation of gene transcription and DNA damage response.
Biological function summary

ATMIN interacts with proteins involved in DNA repair mechanisms. It forms a part of the DNA damage response pathway and modulates activities to maintain genomic integrity. ATMIN's ability to engage with ATM (Ataxia-Telangiectasia Mutated) protein is significant for its function. Through its interaction with ATM ATMIN regulates cellular responses to genotoxic stress contributing to DNA repair cell cycle regulation and apoptosis.

Pathways

ATMIN's role links closely to the DNA damage response and oxidative stress pathways. It cooperates with ATM kinase which acts as a central player in these pathways. By partnering with ATM ATMIN facilitates repair processes and stabilizes the genome. Moreover ATMIN's regulation of transcription factors influences oxidative stress response integrating with broader cellular mechanisms for maintaining cellular integrity under stress conditions.

ATMIN has implications in cancer and neurodegenerative diseases. Altered function or expression of ATMIN can contribute to tumorigenesis due to impaired DNA repair processes. Its interaction with ATM becomes critical in understanding its contribution to such pathologies. Furthermore ATMIN's involvement in oxidative stress response pathways links it to neurodegenerative diseases where oxidative damage is a contributing factor. Understanding these relationships can lead to better therapeutic strategies targeting ATMIN and associated pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
See full target information ATMIN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of ovarian research 17:188 PubMed39289738

2024

Mechanism study of YangJing ZhongYu decoction on regulating mitochondrial dynamics of ovarian granular cells and improving diminished ovarian reserve.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Jilin Kuang
View all publications
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Product promise

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