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AB181269

Anti-ATP13A5 antibody

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(1 Publication)

Rabbit Polyclonal ATP13A5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATP13A5 aa 500-650.

View Alternative Names

UNQ488/PRO1004, ATP13A5, Probable cation-transporting ATPase 13A5, P5-ATPase isoform 5

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP13A5 antibody (AB181269)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP13A5 antibody (AB181269)

Immunohistochemical analysis of paraffin embedded Human kidney tissue labeling ATP13A5 with ab181269 at 1/50.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATP13A5 aa 500-650. The exact immunogen used to generate this antibody is proprietary information.

Q4VNC0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATP13A5 also known as P5B-ATPase is a member of the P-type ATPase superfamily. This protein functions as a cation transporter across cellular membranes. ATP13A5 has a molecular mass of approximately 150 kDa. Expression of ATP13A5 occurs mainly in neurons within the cerebral cortex and hippocampus. Detailed analyses show that ATP13A5 activity influences ion homeostasis and transport demonstrating its importance in cellular health and signaling.
Biological function summary

ATP13A5 plays an essential role in maintaining cellular ion balance. It functions as part of a transport complex involved in regulating manganese homeostasis. Proper manganese levels are critical for neuronal cell function and survival making ATP13A5 indispensable for brain health. The protein's activity helps neurons to manage oxidative stress an important factor in preventing cell damage.

Pathways

ATP13A5 participates in manganese metabolism and ion transport pathways. It partners with proteins like ATP13A2 which also influences ion homeostasis in neuronal cells. The two proteins display functional overlap acting synergistically to preserve neuronal health by controlling manganese levels. Disruption in these pathways can lead to impaired cellular homeostasis and oxidative stress.

ATP13A5 mutations have been linked to complex hereditary parkinsonism. This disorder presents with movement abnormalities and has connections to oxidative stress due to improper ion management. ATP13A5 also associates with neuronal ceroid lipofuscinoses (NCL) a condition marked by progressive neurodegeneration. Both ATP13A2 and ATP13A5 are implicated in these disorders illustrating the importance of coordinated ion transport in preventing neurodegenerative diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ATP13A5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 18:4239-4246 PubMed30221720

2018

Long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 controls glioma cell proliferation and apoptosis via regulation of the microRNA‑224‑5p/tumor protein D52 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yongqiang Zhang,Ying Li,Jing Wang,Ping Lei
View all publications
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Product promise

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