Anti-ATP5D antibody [4D11]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ATP5D also known as ATP synthase subunit delta is a part of the mitochondrial ATP synthase complex. This protein plays a role in the conversion of ADP to ATP by facilitating proton flow across mitochondrial membranes. ATP5D has a molecular mass of approximately 18-20 kDa. Expression of ATP5D occurs in tissues with high energy demands such as the heart skeletal muscle and liver reflecting its role in energy metabolism.

Biological function summary

ATP5D contributes to the production of cellular energy by acting as an essential subunit in the F1 region of the F1Fo ATP synthase complex. This complex is responsible for ATP synthesis during oxidative phosphorylation. ATP5D's role is critical for maintaining the structural integrity and function of the ATP synthase complex. Its presence ensures efficient ATP production essential for various cellular processes.

Pathways

ATP5D functions within oxidative phosphorylation and energy metabolism pathways. It is closely associated with other ATP synthase subunits required for the ATP production process. Complex interactions include interactions with proteins such as ATP5A and ATP5B within the ATP synthase complex which work together in the energy production pathway essential for cell survival.

Associated diseases and disorders

Defects or mutations in ATP5D can be related to mitochondrial diseases like mitochondrial encephalomyopathy. Alterations in its normal function can lead to improper cellular energy production. Additionally ATP5D mutations may impact disorders like Leigh syndrome where mitochondrial dysfunction plays a critical role. Understanding ATP5D's connections including those with proteins involved in these disorders helps unravel its impact on these conditions.