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AB176771

Anti-ATP6V1C2 antibody

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(2 Publications)

Rabbit Polyclonal ATP6V1C2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATP6V1C2 aa 1-200.

View Alternative Names

V-type proton ATPase subunit C 2, V-ATPase subunit C 2, Vacuolar proton pump subunit C 2, ATP6V1C2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1C2 antibody (AB176771)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1C2 antibody (AB176771)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal heart tissue labeling ATP6V1C2 with ab176771 at 1/100 dilution.

Western blot - Anti-ATP6V1C2 antibody (AB176771)
  • WB

Supplier Data

Western blot - Anti-ATP6V1C2 antibody (AB176771)

All lanes:

Western blot - Anti-ATP6V1C2 antibody (ab176771) at 1/500 dilution

Lane 1:

Human fetal kidney lysate

Lane 2:

Mouse kidney lysate

Predicted band size: 49 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATP6V1C2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q8NEY4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATP6V1C2 also known as V-type proton ATPase subunit C 2 is part of the vacuolar ATPase (V-ATPase) complex. This protein performs a mechanical role in transporting hydrogen ions (H+) across cellular membranes which is essential for acidification within various intracellular compartments. The ATP6V1C2 subunit has a molecular mass of approximately 43 kDa. Researchers find that its expression occurs widely throughout the body with notable presence in tissues like the kidney and brain.
Biological function summary

ATP6V1C2 is integral to the V-ATPase complex which participates in maintaining intracellular pH and ion homeostasis. This complex helps in organellar acidification influencing processes such as protein degradation receptor-mediated endocytosis and synaptic vesicle cycling. Among its biological roles ATP6V1C2 ensures the proper function of lysosomal and endosomal pathways promoting cellular metabolism and nutrient processing.

Pathways

ATP6V1C2 has critical roles in biomolecular pathways involved in pH regulation and vesicular trafficking. It is central to pathways like lysosomal acidification and endocytosis. ATP6V1C2 works in conjunction with other V-ATPase subunits such as ATP6V0A4 to facilitate these processes. Through these pathways ATP6V1C2 modulates both macromolecule turnover and neurotransmitter release showcasing its versatile role in cellular metabolism.

ATP6V1C2 links to conditions such as distal renal tubular acidosis and neurodegenerative diseases. Mutations or dysfunction in its associated V-ATPase unit can lead to impaired acidification of urine or defective lysosomal degradation respectively. The protein has interactions with ATP6V0D1 highlighting its involvement in these diseases. By understanding ATP6V1C2’s role researchers can investigate new therapeutic approaches for related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
See full target information ATP6V1C2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Genes 14: PubMed36980869

2023

Distribution and Expression of Pulmonary Ionocyte-Related Factors CFTR, ATP6V0D2, and ATP6V1C2 in the Lungs of Yaks at Different Ages.

Applications

Unspecified application

Species

Unspecified reactive species

Junfeng He,Yating Wei,Yan Cui,Qian Zhang

Nature communications 10:2426 PubMed31160578

2019

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.

Applications

Unspecified application

Species

Unspecified reactive species

Philippe Coulombe,Joelle Nassar,Isabelle Peiffer,Slavica Stanojcic,Yvon Sterkers,Axel Delamarre,Stéphane Bocquet,Marcel Méchali
View all publications
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