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AB182626

Anti-ATRIP (phospho S68) antibody

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(1 Publication)

Rabbit Polyclonal ATRIP phospho S68 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATRIP phospho S68 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

AGS1, ATRIP, ATR-interacting protein, ATM and Rad3-related-interacting protein

1 Images
Western blot - Anti-ATRIP (phospho S68) antibody (AB182626)
  • WB

Supplier Data

Western blot - Anti-ATRIP (phospho S68) antibody (AB182626)

All lanes:

Western blot - Anti-ATRIP (phospho S68) antibody (ab182626) at 1/500 dilution

Lane 1:

Extracts from 3T3 cells with Antigen-specific peptide

Lane 2:

Extracts from 3T3 cells

Predicted band size: 86 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ATRIP phospho S68 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8WXE1

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Alternative Products

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Primary Antibodies

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATRIP also known as ATRIP protein serves as an essential component within the ATR-ATRIP complex which is vital in the DNA damage response. ATRIP is a protein that weighs approximately 86 kDa and is most commonly expressed in the nucleus of cells. It functions primarily by binding to ATR (Ataxia Telangiectasia and Rad3-related protein) which enables the ATR to localize to sites of DNA damage and replication stress. This enables the recognition and repair of damaged DNA preventing genomic instability.
Biological function summary

ATRIP plays roles in maintaining genome integrity. It forms a stable complex with ATR which is important for the activation of ATR kinase activity. ATRIP directly interacts with single-stranded DNA coated by replication protein A (RPA) to perform its functions. By facilitating ATR recruitment to DNA damage sites ATRIP aids in the initiation of DNA repair mechanisms which are critical for normal cellular function and survival.

Pathways

ATRIP's activities are an integral part of the DNA damage signaling and repair pathways. ATR-ATRIP complex is central to the DNA replication checkpoint pathway where it maintains replication fork stability and controls cell cycle progression. Additionally ATRIP is involved in pathways alongside proteins like CHK1 which it helps to activate in response to DNA damage ensuring proper cell cycle arrest and repair processes.

ATRIP is implicated in certain cancers and genomic instability syndromes. Deficient ATRIP function can correlate with a higher predisposition to cancers due to defective DNA damage response and repair. Further the ATR-ATRIP interaction can influence the onset and progression of Seckel syndrome where defects in ATRIP or its partner ATR might lead to developmental abnormalities. The role of ATRIP in these diseases highlights the importance of maintaining genomic stability through effective DNA repair mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
See full target information ATRIP phospho S68
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

CNS neuroscience & therapeutics 31:e70413 PubMed40384564

2025

Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Yu,Minghong Xie,Xuancong Liufu,Yezi Xu,Lei Chen
View all publications
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Product promise

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