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AB122437

Anti-ATRNL1 antibody

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(1 Publication)

Rabbit Polyclonal ATRNL1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATRNL1 aa 800-950.

View Alternative Names

KIAA0534, ATRNL1, Attractin-like protein 1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATRNL1 antibody (AB122437)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATRNL1 antibody (AB122437)

ab122437, at a 1/20 dilution, staining ATRNL1 in paraffin embedded Human small intestine tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATRNL1 aa 800-950. The exact immunogen used to generate this antibody is proprietary information.

Q5VV63

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATRNL1 also known as Attractin-like 1 is a protein involved in cell signaling and communication. The protein weighs approximately 151 kDa. It is expressed in several tissues including the central nervous system and some peripheral tissues. ATRNL1 is part of a family of proteins that include Attractin and shares structural similarities with proteins involved in neuroendocrine functions.
Biological function summary

ATRNL1 plays a role in cell growth and differentiation influencing neural development. It does not seem to form part of a known protein complex but influences signaling pathways critical for neurodevelopment. Researchers have shown interest in its function in brain regions where neurogenesis and neuron differentiation occur.

Pathways

ATRNL1 is involved in the neurotrophin signaling pathway critical for neuronal survival and differentiation. It shares connections with neurotrophic proteins like NGF and BDNF in these pathways. ATRNL1 influences neuroplasticity through regulating the availability of these neurotrophins thereby modulating cellular responses downstream in neural tissues.

ATRNL1 has been studied in relation to neurodevelopmental disorders and neurodegenerative diseases. In autism spectrum disorders ATRNL1 may influence neuron connectivity and signaling through interactions with regulatory proteins like MECP2. Additionally its altered expression has been noted in Alzheimer’s disease where it may impact amyloid-beta homeostasis alongside proteins such as APP suggesting potential involvement in neural degeneration.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in melanocortin signaling pathways that regulate energy homeostasis.
See full target information ATRNL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 35:65-73 PubMed30715488

2019

Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia.

Applications

Unspecified application

Species

Unspecified reactive species

Nadine Kaesler,Claudia Goettsch,Daniel Weis,Leon Schurgers,Burkhard Hellmann,Jürgen Floege,Rafael Kramann
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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