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AB224142

Anti-Atrophin 1 antibody

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(1 Publication)

Rabbit Polyclonal Atrophin 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATN1 aa 500-700.

View Alternative Names

D12S755E, DRPLA, ATN1, Atrophin-1, Dentatorubral-pallidoluysian atrophy protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Atrophin 1 antibody (AB224142)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Atrophin 1 antibody (AB224142)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for Atrophin 1 (green) using ab224142 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Atrophin 1 antibody (AB224142)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Atrophin 1 antibody (AB224142)

Paraffin-embedded human placenta tissue stained for Atrophin 1 using ab224142 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ATN1 aa 500-700. The exact immunogen used to generate this antibody is proprietary information.

P54259

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Atrophin 1 also known by names like Atropin is a protein involved in transcriptional regulation. It has a mass of approximately 230 kDa. This protein exhibits wide expression in the body with detectable levels in neuronal tissues and the brain. Atrophin 1 functions to interact with other proteins influencing gene expression through modulation of chromatin structure.
Biological function summary

Atrophin 1 serves essential roles in cellular processes by acting as a transcriptional co-repressor. It participates in developmental functions and neural growth. Atrophin 1 becomes part of protein complexes that alter gene expression by modifying chromatin states. This role connects it with several developmental regulatory networks.

Pathways

Atrophin 1 engages in signaling networks especially those relating to neural development and apoptosis. It interacts within the Notch signaling pathway a significant regulator of cell fate decisions. Atrophin 1 also interfaces with proteins like RBP-Jk facilitating transcriptional output from Notch signaling.

Atrophin 1 is tightly associated with Dentatorubral-pallidoluysian atrophy (DRPLA) a neurodegenerative disorder. In DRPLA Atrophin 1 undergoes polyglutamine expansion resulting in protein misfolding and aggregation. The abnormally expanded Atrophin 1 affects neural integrity. Connections with other proteins like huntingtin which also involves polyglutamine expansions hint at shared disease mechanisms and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
See full target information ATN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:1185 PubMed34475975

2021

Detection of mitochondrial coupling factor 6 in placental tissues from preeclamptic pregnancies and its influence on biological behavior of trophoblast cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wanyu Song,Xufeng Shi,Kan Liu,Ranhong Li,Leilei Niu,Lijun Su,Haiying Wu
View all publications
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Product promise

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