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AB99304

Anti-ATXN2L antibody

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(1 Publication)

Rabbit Polyclonal ATXN2L antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATXN2L aa 150-200.

View Alternative Names

A2D, A2LG, A2LP, A2RP, ATXN2L, Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein

2 Images
Western blot - Anti-ATXN2L antibody (AB99304)
  • WB

Unknown

Western blot - Anti-ATXN2L antibody (AB99304)

All lanes:

Western blot - Anti-ATXN2L antibody (ab99304) at 0.04 µg/mL

Lane 1:

Hela whole cell lysate at 50 µg

Lane 2:

Hela whole cell lysate at 15 µg

Lane 3:

Hela whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 50 µg

Predicted band size: 113 kDa

true

Exposure time: 30s

Immunoprecipitation - Anti-ATXN2L antibody (AB99304)
  • IP

Unknown

Immunoprecipitation - Anti-ATXN2L antibody (AB99304)

ab99304, at 0.1 μg/ml, staining ATXN2L in HeLa whole cell lysate immunoprecipitated using ab99304 at 3 μg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-ATXN2L antibody (ab99304)

Predicted band size: 113 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human ATXN2L aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

Q8WWM7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Elephant": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATXN2L also known as ataxin-2-like protein is a protein encoded by the ATXN2L gene. This protein has a mass of approximately 130 kilodaltons. It is widely expressed in various tissues including the brain and liver. Structurally ATXN2L contains multiple HEAT repeat sequences which facilitate its role in protein-protein interactions. The protein localizes primarily to the cytoplasm and is involved in the modulation of RNA metabolism.
Biological function summary

The ATXN2L protein interacts with other cellular components to influence mRNA stability and translation. It forms part of RNA granules structures that play a significant role in the post-transcriptional regulation of gene expression. Through these interactions ATXN2L can affect the cellular response to stress by managing the translation of stress response genes. Its function is critical in maintaining proper RNA homeostasis under various cellular conditions.

Pathways

Various interacting partners connect ATXN2L to fundamental biological processes. It is involved in the insulin signaling pathway which is important for energy balance and cellular growth. Additionally it participates in stress granule assembly involving other proteins such as G3BP1 and EIF2α. These pathways highlight the protein's importance in cellular stress responses and metabolism regulation.

Disruptions in ATXN2L function are associated with neurodegenerative conditions and metabolic syndrome. Mutations or altered expressions may link to amyotrophic lateral sclerosis (ALS) where it interacts with proteins like TDP-43 influencing disease progression. Furthermore its role in the insulin signaling pathway connects ATXN2L to type 2 diabetes implicating it in the development of insulin resistance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the regulation of stress granule and P-body formation.
See full target information ATXN2L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:112419 PubMed37074914

2023

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function.

Applications

Unspecified application

Species

Unspecified reactive species

Branka Popović,Benoît P Nicolet,Aurélie Guislain,Sander Engels,Anouk P Jurgens,Natali Paravinja,Julian J Freen-van Heeren,Floris P J van Alphen,Maartje van den Biggelaar,Fiamma Salerno,Monika C Wolkers
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB184834

Anti-ATXN2L antibody

primary-antibodies

atxn2l-antibody-ab184834

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